Detailed information of TA system TA153245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2640310..2641898
• Replicon: chromosome
• Accession: NZ_CP050829
• Organism: Klebsiella pneumoniae strain Bckp067

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486JB51
• Locus tag: HC709_RS13275
• Protein ID: WP_023316847.1
• Coordinates: 2640310..2641632 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HC709_RS13280
• Protein ID: WP_002904790.1
• Coordinates: 2641632..2641898 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC709_RS13260	2635366..2637867	+	2502	WP_069334993.1	fimbrial biogenesis outer membrane usher protein	-
HC709_RS13265	2637855..2638859	+	1005	WP_048337093.1	type 1 fimbrial protein	-
HC709_RS13270	2639001..2640293	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HC709_RS13275	2640310..2641632	-	1323	WP_023316847.1	type II toxin-antitoxin system HipA family toxin	Toxin
HC709_RS13280	2641632..2641898	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HC709_RS13285	2642170..2642496	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
HC709_RS13290	2642493..2642993	-	501	WP_060589175.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HC709_RS13295	2642971..2644350	-	1380	WP_004215088.1	purine permease	-
HC709_RS13300	2644696..2645850	+	1155	WP_048265552.1	FAD-dependent urate hydroxylase HpxO	-
HC709_RS13305	2645831..2646754	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49141.44 Da
• Isoelectric Point: 7.5357

>T153245 WP_023316847.1 NZ_CP050829:c2641632-2640310 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T153245 NZ_CP066809:c2729572-2729198 [Shigella flexneri 3a]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT153245 WP_002904790.1 NZ_CP050829:c2641898-2641632 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT153245 NZ_CP066809:c2729993-2729619 [Shigella flexneri 3a]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Structures

Toxin

• AlphaFold DB: A0A486JB51

Antitoxin

• AlphaFold DB: A0A0H3GXD8