Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825276..825933 Replicon chromosome
Accession NZ_CP050829
Organism Klebsiella pneumoniae strain Bckp067

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HC709_RS04230 Protein ID WP_002916310.1
Coordinates 825523..825933 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HC709_RS04225 Protein ID WP_002916312.1
Coordinates 825276..825542 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC709_RS04200 820432..821865 - 1434 WP_040219565.1 6-phospho-beta-glucosidase -
HC709_RS04205 821984..822712 - 729 WP_117053803.1 MurR/RpiR family transcriptional regulator -
HC709_RS04210 822762..823073 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HC709_RS04215 823237..823896 + 660 WP_002916317.1 hemolysin III family protein -
HC709_RS04220 824047..825030 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HC709_RS04225 825276..825542 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HC709_RS04230 825523..825933 + 411 WP_002916310.1 protein YgfX Toxin
HC709_RS04235 825940..826461 - 522 WP_004144730.1 flavodoxin FldB -
HC709_RS04240 826562..827458 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HC709_RS04245 827481..828194 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HC709_RS04250 828200..829933 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T153233 WP_002916310.1 NZ_CP050829:825523-825933 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T153233 NZ_CP066807:70630-70779 [Escherichia coli]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT153233 WP_002916312.1 NZ_CP050829:825276-825542 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT153233 NZ_CP066807:c70585-70526 [Escherichia coli]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References