Detailed information of TA system TA153206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4766665..4768346
• Replicon: chromosome
• Accession: NZ_CP050822
• Organism: Klebsiella pneumoniae strain Bckp091

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: HC645_RS23615
• Protein ID: WP_135725749.1
• Coordinates: 4766665..4767582 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: HC645_RS23620
• Protein ID: WP_004177809.1
• Coordinates: 4767588..4768346 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC645_RS23595	4761971..4763491	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
HC645_RS23600	4763488..4764486	+	999	WP_002885172.1	ribose ABC transporter permease	-
HC645_RS23605	4764517..4765458	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HC645_RS23610	4765533..4766540	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
HC645_RS23615	4766665..4767582	-	918	WP_135725749.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HC645_RS23620	4767588..4768346	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HC645_RS23625	4768432..4769160	-	729	WP_002885152.1	response regulator transcription factor	-
HC645_RS23630	4769433..4771580	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
HC645_RS23635	4772042..4772728	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34759.22 Da
• Isoelectric Point: 5.2585

>T153206 WP_135725749.1 NZ_CP050822:c4767582-4766665 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSEMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T153206 NZ_CP066806:231281-231388 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT153206 WP_004177809.1 NZ_CP050822:c4768346-4767588 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT153206 NZ_CP066806:c231232-231169 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Antitoxin

• AlphaFold DB: A6TH05