Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4605406..4605922 Replicon chromosome
Accession NZ_CP050822
Organism Klebsiella pneumoniae strain Bckp091

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HC645_RS22795 Protein ID WP_002886902.1
Coordinates 4605406..4605690 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HC645_RS22800 Protein ID WP_002886901.1
Coordinates 4605680..4605922 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC645_RS22770 4600822..4601130 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
HC645_RS22775 4601215..4601388 + 174 WP_032410138.1 hypothetical protein -
HC645_RS22780 4601391..4602134 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
HC645_RS22785 4602491..4604629 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HC645_RS22790 4604938..4605402 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HC645_RS22795 4605406..4605690 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HC645_RS22800 4605680..4605922 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HC645_RS22805 4606000..4607910 - 1911 WP_009486549.1 BglG family transcription antiterminator -
HC645_RS22810 4607933..4609087 - 1155 WP_023302389.1 lactonase family protein -
HC645_RS22815 4609154..4609894 - 741 WP_104468345.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T153205 WP_002886902.1 NZ_CP050822:c4605690-4605406 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T153205 NZ_CP066806:175810-175995 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT153205 WP_002886901.1 NZ_CP050822:c4605922-4605680 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT153205 NZ_CP066806:176012-176422 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGG
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References