Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 8401..9140 Replicon plasmid pYRW13-131
Accession NZ_CP050813
Organism Yokenella regensburgei strain W13

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HEC60_RS24725 Protein ID WP_167810230.1
Coordinates 8401..8886 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HEC60_RS24730 Protein ID WP_167810231.1
Coordinates 8874..9140 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC60_RS24700 4617..4979 + 363 WP_167810227.1 hypothetical protein -
HEC60_RS24705 5027..5368 - 342 Protein_4 IS4/IS5 family transposase -
HEC60_RS24710 5812..5949 - 138 Protein_5 IS3 family transposase -
HEC60_RS24715 5995..6189 - 195 WP_167810228.1 DnaJ domain-containing protein -
HEC60_RS24720 6715..8244 + 1530 WP_167810229.1 IS3 family transposase -
HEC60_RS24725 8401..8886 - 486 WP_167810230.1 GNAT family N-acetyltransferase Toxin
HEC60_RS24730 8874..9140 - 267 WP_167810231.1 DUF1778 domain-containing protein Antitoxin
HEC60_RS24735 9341..10093 - 753 WP_167810232.1 AraC family transcriptional regulator -
HEC60_RS24740 10580..10732 - 153 Protein_11 IS3 family transposase -
HEC60_RS24745 10819..11556 + 738 WP_167810233.1 IS21-like element helper ATPase IstB -
HEC60_RS24750 11734..12438 + 705 Protein_13 IS6 family transposase -
HEC60_RS24755 12446..13342 - 897 WP_167810234.1 DUF4158 domain-containing protein -
HEC60_RS24760 13493..14074 + 582 WP_167810235.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - prgI / spaP / invC/sctN / invA 1..131292 131292
- inside IScluster/Tn - - 626..17683 17057


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(48-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17583.50 Da        Isoelectric Point: 9.9099

>T153188 WP_167810230.1 NZ_CP050813:c8886-8401 [Yokenella regensburgei]
VGRVTAPKPLSTSHQLAEFVRGEVVLDDWLKQRGLKNQALGVARTFVVCKTGMKVVVGFYSLATGSVNHVEATGSLRRNM
PDPIPVIILTRLAVDVSFRGNGLGADLLQDAVLRCYRVAENIGVCAIMVHALAEEAKGFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T153188 NZ_CP066794:c3192009-3191851 [Erwinia amylovora]
ATGAAACTGCCAGCGAACTGTCTTATCTGGTGCGTACTTATAGTGTGTGTCACGCTTTTAATATTCACATATCTGACACG
AAAATCGCTCTGCGAAATTCGCTATAAGGATGGTTACAGGGAGGTGGCCGCTTTCATGGCTTACGAATCCGGCAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10128.54 Da        Isoelectric Point: 4.4720

>AT153188 WP_167810231.1 NZ_CP050813:c9140-8874 [Yokenella regensburgei]
MKSDIQLNLRTKESQRALIDAAAEILHKSHTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDLLDAPVVDDPAMNKLL
ARKPQWDV

Download         Length: 267 bp

>AT153188 NZ_CP066794:3192063-3192109 [Erwinia amylovora]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References