Detailed information of TA system TA153186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4795132..4795753
• Replicon: chromosome
• Accession: NZ_CP050811
• Organism: Yokenella regensburgei strain W13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HEC60_RS23060
• Protein ID: WP_167809983.1
• Coordinates: 4795132..4795338 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A6H0KF34
• Locus tag: HEC60_RS23065
• Protein ID: WP_038254270.1
• Coordinates: 4795340..4795753 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEC60_RS23040	4791696..4791968	+	273	WP_002444653.1	DNA-binding protein HU-beta	-
HEC60_RS23045	4792171..4794045	+	1875	WP_006818788.1	peptidylprolyl isomerase	-
HEC60_RS23050	4794194..4794565	+	372	WP_167809981.1	helix-hairpin-helix domain-containing protein	-
HEC60_RS23055	4794681..4795079	+	399	WP_167809982.1	YbgC/FadM family acyl-CoA thioesterase	-
HEC60_RS23060	4795132..4795338	+	207	WP_167809983.1	type II toxin-antitoxin system HicA family toxin	Toxin
HEC60_RS23065	4795340..4795753	+	414	WP_038254270.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HEC60_RS23070	4795787..4796482	-	696	WP_006818793.1	7-cyano-7-deazaguanine synthase QueC	-
HEC60_RS23075	4796549..4798249	-	1701	WP_167809984.1	SgrR family transcriptional regulator	-
HEC60_RS23080	4798372..4799190	+	819	WP_167809985.1	HMP-PP phosphatase	-
HEC60_RS23085	4799240..4800289	-	1050	WP_161616819.1	PLP-dependent cysteine synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4786943..4804444	17501

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7679.05 Da
• Isoelectric Point: 12.2532

>T153186 WP_167809983.1 NZ_CP050811:4795132-4795338 [Yokenella regensburgei]
MNSKALIAELVADGWILIRVTGSHHHFRHPIKTGLVTVPHPKKDLPVGTVKSIRRQARVSNPVMHSWR

Nucleotide

• Length: 207 bp

>T153186 NZ_CP066794:1898616-1898795 [Erwinia amylovora]
ATGGATAGCAGGAATGCAATAGCAATGATAGAGGCCGATGGATGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGGGCTGGTAACGGTAAAACATCCCCAAAAGGACATACCGCTACCAACGCTGAAAAGCATTA
AAAAACAGGCGGGGCTTTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 14870.04 Da
• Isoelectric Point: 4.3744

>AT153186 WP_038254270.1 NZ_CP050811:4795340-4795753 [Yokenella regensburgei]
MYYPIAVENGDDVHAWGVIVPDLPGCFSAGDTLEEAMINASEAITAHIELLIEMGDDIPPVSSISDLVGHSQYQGMAWAL
VDIDLTRLLGGSEKINVTLPKVLIDRIDRCVARHPEFKSRSGFLAQAAIERITKPGL

Nucleotide

• Length: 414 bp

>AT153186 NZ_CP066794:1898818-1899228 [Erwinia amylovora]
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCCGATATTCCAGGCTGCTTCTCTGG
CGGCGACAATTATCAGGATGCGATTGAGAGCGCGCGTGAGGCTATCGACGCGCATATCGAATTACTGGTGGAAGATGGCG
AAGCGGTGCCGGAAGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTTGGTGTGGTGTGGGCGCTGGTAGAT
GTGGACGTTACCCGGCTGATGGGGAAAGCGGAAAAAATCAATGTTACGCTCCCTTCTTTACTGATCCGCCGTATCGATCA
GTTTGTCGCTGCACATCCTGAGTACGGTAGCCGTTCCGGCTTCCTGTCCCGCGTGGCGGCTGATAAAGTGATTGGTCGCG
AAAAACGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A6H0KF34