Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3773521..3774137 Replicon chromosome
Accession NZ_CP050811
Organism Yokenella regensburgei strain W13

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HEC60_RS18225 Protein ID WP_081874630.1
Coordinates 3773766..3774137 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HEC60_RS18220 Protein ID WP_167809729.1
Coordinates 3773521..3773763 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC60_RS18190 3769191..3769964 + 774 WP_167809728.1 winged helix-turn-helix domain-containing protein -
HEC60_RS18195 3769961..3770425 + 465 WP_038253430.1 hypothetical protein -
HEC60_RS18200 3770521..3771117 + 597 WP_006817995.1 glucose-1-phosphatase -
HEC60_RS18205 3771114..3771974 + 861 WP_006817994.1 virulence factor BrkB family protein -
HEC60_RS18210 3771971..3772408 + 438 WP_006817993.1 D-tyrosyl-tRNA(Tyr) deacylase -
HEC60_RS18215 3772450..3773391 + 942 WP_040903128.1 fatty acid biosynthesis protein FabY -
HEC60_RS18220 3773521..3773763 + 243 WP_167809729.1 ribbon-helix-helix protein, CopG family Antitoxin
HEC60_RS18225 3773766..3774137 + 372 WP_081874630.1 type II toxin-antitoxin system VapC family toxin Toxin
HEC60_RS18230 3774181..3775110 - 930 WP_006817988.1 formate dehydrogenase accessory protein FdhE -
HEC60_RS18235 3775107..3775742 - 636 WP_006817987.1 formate dehydrogenase cytochrome b556 subunit -
HEC60_RS18240 3775739..3776641 - 903 WP_006817986.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13551.74 Da        Isoelectric Point: 6.8710

>T153184 WP_081874630.1 NZ_CP050811:3773766-3774137 [Yokenella regensburgei]
MEHMAVFDTNILIDLFNNRMEAADAIESTATHRAISLITWMEVLVGARKHGQEAKTAAVMSAFEIIDVSREIAERSVLLR
VKHGMKLPDAIILATAQSKNCQLISRNTKDFAGIAGVISPYQL

Download         Length: 372 bp

>T153184 NZ_CP066794:c1084045-1083827 [Erwinia amylovora]
ATGACTGACAAACTTCTAACGAAAACTGACTACCTGATGCGCCTCAGGCGTTGTCGTTCAATCGATACACTTGAACGCGT
GATTGAAAAGAACAAGTACGAATTATCTGATGATGAACTGGCTGTATTTTATTCAGCCGCCGATCACCGTCTTGCTGAAC
TAACCATGAATAAGCTGTACGACAAAGTACCGGTCGCTGTCTGGAAGTTTGTCCGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9411.63 Da        Isoelectric Point: 4.1657

>AT153184 WP_167809729.1 NZ_CP050811:3773521-3773763 [Yokenella regensburgei]
MSLVVDLDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIEQYLDKQGASVIREALGLWGDQEEDGLEYERKLREEW

Download         Length: 243 bp

>AT153184 NZ_CP066794:c1084454-1084065 [Erwinia amylovora]
ATGGACGAATACTCACCGAAAAGGCATGATATTGCGCAGCTGAAATTCTTATGTGAAAACCTGTATGATGAAAGTCTGGC
TACGTTAGGCGACAGCCATCATGGCTGGGTTAACGACCCCACCTCAACGAGCAATCTTCAGCTTAACGACCTGATAGAGC
ACATTGCAGCATTCACAATGAATTACAAAATCAAGCATATCGAAGACAGCGATCTGATAAGTCAAATTGATGAGTATCTG
GACGACACCTTTATGCTTTTCAGCAATTACGGTGTCAACAATCTTGACTTACAACGCTGGCAAAAATCAGCGAAGCGATT
GTTTAACATTTTTGCTAAAGAATGCGTAATGAGCCAGATCCAGTCCAGCCATTCATTTAGCAGCCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References