Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3562574..3563181 Replicon chromosome
Accession NZ_CP050811
Organism Yokenella regensburgei strain W13

Toxin (Protein)


Gene name hicA Uniprot ID A0A6H0KC19
Locus tag HEC60_RS17215 Protein ID WP_072009046.1
Coordinates 3562984..3563181 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A6H0KD19
Locus tag HEC60_RS17210 Protein ID WP_038253675.1
Coordinates 3562574..3562981 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC60_RS17195 3558154..3558975 - 822 WP_006817727.1 AraC family transcriptional regulator -
HEC60_RS17200 3559203..3560603 + 1401 WP_167809666.1 MFS transporter -
HEC60_RS17205 3560614..3562569 + 1956 WP_167809667.1 glycoside hydrolase family 127 protein -
HEC60_RS17210 3562574..3562981 - 408 WP_038253675.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HEC60_RS17215 3562984..3563181 - 198 WP_072009046.1 type II toxin-antitoxin system HicA family toxin Toxin
HEC60_RS17220 3563402..3564940 - 1539 WP_006817732.1 aldehyde dehydrogenase -
HEC60_RS17225 3565033..3566184 - 1152 WP_167809668.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7328.56 Da        Isoelectric Point: 11.1481

>T153183 WP_072009046.1 NZ_CP050811:c3563181-3562984 [Yokenella regensburgei]
VTSADVITILKKQGWIQKRVKGSHHQFCHPNLPGLVTVPHPRKDIKPGTLAQIWRQAGIKPSREE

Download         Length: 198 bp

>T153183 NZ_CP066794:725682-726101 [Erwinia amylovora]
GTGGTCCTGTGGCAATGTGAACTGCGGCCATCAAGGCTGGCACAGCGGTTTTCGCTGCTGCTGCATGGGGCAGTGATGCT
GGCGCTGCTATTGCCGACATGGCCCGCCAGCTCTGGCCTGGTGCGGATGCTGTTGCTGGTTTTGGTACTGTTGGAGTGCA
TACGCAGTCGGCGGCGCATTGGTCGTCGCCAGGGGGATATCGCTCTGTTGGAAGGGCATGAGCTACGCTGGCGTCAACGC
GAGTGGTGCATTATTTCCCGTCCGTGGCTGACCGGGCAGGCAATCCTGCTGTTACTACAGGATACTCATGGACAGCGCGA
GCGACTATGGCTGTTCGCCGACGGCATGGAAAAACGTAACTGGCGTCAGCTGCGCCTGCAATTGCTGAACAGTAAAGTAC
AGGGGAATGGCTGGTGCTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14962.75 Da        Isoelectric Point: 4.3371

>AT153183 WP_038253675.1 NZ_CP050811:c3562981-3562574 [Yokenella regensburgei]
MFYPAYIHADPDGSASGFFPDVPGCYFAGDTLDEAFQDAKSALVAHFELLYEMEDALPGPGVVEKHLETHPEDFSGGQWL
LVDINMSQFDGRAERINITIPRRLLVKIDSFVSEHSDFANRSAFLAEAARRVLPG

Download         Length: 408 bp

>AT153183 NZ_CP066794:725435-725701 [Erwinia amylovora]
ATGGATATTACAAATAAATCACGTATTCACTGGGCATGCCGTCGCGGCATGCGCGAGCTGGATATCTCGATCATGCCCTT
TTTCCAGTATGAATTTGACTCGCTGAACGACAGCGATAAACGGCTGTTCGTTCGCCTGCTGGAGAGCGATGACCCGGACC
TGTTCAACTGGCTGATGAACCACGGCGAGCCGGCAGACGTGGAGCTGAAAAGGATGGTGGCGCTAATCCAACAAAGAAAT
AAACAACGTGGTCCTGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H0KC19

Antitoxin

Source ID Structure
AlphaFold DB A0A6H0KD19

References