Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2890642..2891299 Replicon chromosome
Accession NZ_CP050811
Organism Yokenella regensburgei strain W13

Toxin (Protein)


Gene name cptA Uniprot ID A0A6H0KAP8
Locus tag HEC60_RS13975 Protein ID WP_038255496.1
Coordinates 2890642..2891052 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G9Z364
Locus tag HEC60_RS13980 Protein ID WP_006818408.1
Coordinates 2891033..2891299 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC60_RS13955 2886677..2888410 - 1734 WP_006818413.1 single-stranded-DNA-specific exonuclease RecJ -
HEC60_RS13960 2888416..2889129 - 714 WP_038255492.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HEC60_RS13965 2889152..2890048 - 897 WP_167809506.1 site-specific tyrosine recombinase XerD -
HEC60_RS13970 2890150..2890636 + 487 Protein_2741 flavodoxin FldB -
HEC60_RS13975 2890642..2891052 - 411 WP_038255496.1 protein YgfX Toxin
HEC60_RS13980 2891033..2891299 - 267 WP_006818408.1 FAD assembly factor SdhE Antitoxin
HEC60_RS13985 2891546..2892529 + 984 WP_167809507.1 tRNA-modifying protein YgfZ -
HEC60_RS13990 2892578..2893231 - 654 WP_006818406.1 hemolysin III family protein -
HEC60_RS13995 2893395..2893706 - 312 WP_006818405.1 N(4)-acetylcytidine aminohydrolase -
HEC60_RS14000 2893705..2894487 + 783 WP_051860955.1 MurR/RpiR family transcriptional regulator -
HEC60_RS14005 2894607..2896040 + 1434 WP_038255500.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16089.01 Da        Isoelectric Point: 11.8921

>T153182 WP_038255496.1 NZ_CP050811:c2891052-2890642 [Yokenella regensburgei]
VVLWQSDLRVSWRAQWLSLLLHGVVAGVVLLMPWPLSYTPLWLLLLSLVVFDCVRSQRRINARQGEIKLLIDSRLRWQNQ
EWDILGTPWILSGGMLLRIRRVGHRRKHHLWLAADSMEAGEWRDLRRIIMQQPAQQ

Download         Length: 411 bp

>T153182 NZ_CP066794:471774-472049 [Erwinia amylovora]
ATGGAAATACAGTGGACCCAAAAGGCCCAGGATGACCTGGAGCGTATTTATAGGTTTGCCTGTCAGTACAGTCGGCAACA
TGCTGACAACGTATTAGAGCGTTTGCTCATAGGAACCTCAGGGCTCGCCGACCATCCAAGAATCGGTGTTTCTCAGATAA
GATATGAACCACGAGAAGTGAGAAAAATCTTGTTTGATGATTATGACGTTCACTATGAAATTCAGCGCGACACTATCTAT
ATTGTTGACCTTTGGCATACCCGAGAGGATCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10488.03 Da        Isoelectric Point: 5.1114

>AT153182 WP_006818408.1 NZ_CP050811:c2891299-2891033 [Yokenella regensburgei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKLLFVRLLECDDPDLFNWLMNHGKPADAGFQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT153182 NZ_CP066794:471522-471770 [Erwinia amylovora]
ATGAGACAACTCGCGAAACAGACGATCAGCGCTCAGATCCCTGCAGAGCTTGCCGCGGCGGTTGAAAACCTGGCTATTGA
ACTGGACAGATCTAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCCATGATTGAAGAGAGAGAGCGGCGGCATCAGCAGA
TTTTGAAAGGGCTTGCTGATGTCGATGCGGGAAGAGTGGTTAGCCATGCGGATGTAGTTGACTTCGCTAACAAACTGAAA
AAATCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H0KAP8

Antitoxin

Source ID Structure
AlphaFold DB G9Z364

References