Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1571349..1571947 Replicon chromosome
Accession NZ_CP050810
Organism Trueperella pyogenes strain jx18

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HEP79_RS07190 Protein ID WP_108726552.1
Coordinates 1571349..1571663 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HEP79_RS07195 Protein ID WP_108726551.1
Coordinates 1571654..1571947 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEP79_RS07160 1566382..1567299 - 918 WP_108726555.1 ABC transporter substrate-binding protein -
HEP79_RS07165 1567408..1567650 + 243 WP_024963636.1 hypothetical protein -
HEP79_RS07170 1567647..1568600 + 954 WP_108726554.1 SRPBCC family protein -
HEP79_RS07175 1568744..1569355 + 612 WP_039663456.1 alpha/beta hydrolase -
HEP79_RS07180 1569487..1569843 - 357 WP_039661774.1 hypothetical protein -
HEP79_RS07185 1570171..1571019 - 849 WP_159081093.1 siderophore-interacting protein -
HEP79_RS07190 1571349..1571663 + 315 WP_108726552.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HEP79_RS07195 1571654..1571947 + 294 WP_108726551.1 putative addiction module antidote protein Antitoxin
HEP79_RS07200 1572054..1572470 + 417 WP_108726550.1 SRPBCC family protein -
HEP79_RS07210 1572870..1573496 - 627 WP_108726549.1 alpha/beta fold hydrolase -
HEP79_RS07215 1573493..1574512 - 1020 WP_039661764.1 hypothetical protein -
HEP79_RS07220 1574572..1575786 - 1215 WP_108726548.1 molybdopterin molybdotransferase MoeA -
HEP79_RS07225 1575870..1576517 + 648 WP_039661760.1 5-formyltetrahydrofolate cyclo-ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1568648..1583097 14449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11875.76 Da        Isoelectric Point: 10.0302

>T153171 WP_108726552.1 NZ_CP050810:1571349-1571663 [Trueperella pyogenes]
VKIRQTDVYAHWFRELKDVQSKARINIALQRCKIAGEVVGDVKPVGDGVFEMRIHVGPGYRIYYMSRGNQLMLLVIGGDK
STQQRDITKAKQLATEIIREGSWE

Download         Length: 315 bp

>T153171 NZ_CP066777:1692967-1693320 [Morganella morganii]
GTGTGGAAGATAATTACAACAGATAATTTTGCAGCGTGGTTTGCTGCGCAGGATGACGGGGATCGTACAGCAATACTGGC
AGCGATGCTGGTATTGGAGAAGACCGGACCCGGTTTATCAGGACCGTATGCGGATACTGTGAAAGGTTCGCGTTATACGA
ATATGAAAGAGTTACGTATACAAAGCAGAGGGCAGCCGATAAGGGCATTTTTTGCATTCGACCCTGAACGGAGAGGTGTT
TTGCTGTGCGCAGGGTATAAAACCGGCAAAGAAAAACGTTTTTATATGCAGATGATTCCGCAGGCTGACCGTGAGTATAC
AGAATGGCTGAACAGGCCGGAAAACAGGAGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10273.77 Da        Isoelectric Point: 4.8004

>AT153171 WP_108726551.1 NZ_CP050810:1571654-1571947 [Trueperella pyogenes]
MGVKISTWDASEYLETKEDIAAYLNAALEEGDPALLQVALGDVAKARGVTAIAREAGVGRESLYKSLSENGNPSWRTITK
VLTALGLKIEVKAIALA

Download         Length: 294 bp

>AT153171 NZ_CP066777:1693323-1693625 [Morganella morganii]
ATGGGAAAGTCACTCAGACAACTGCTGGCTGAGGAAAAGCCGGAAGTCGCGGCAGCAGCACGGGTTCAGGCGGACGAGAT
CCTGCTGAATATCCATCTGGCGGAACTGCGGGAGAAAGTGAACAAAACACAGGTGGAAATGGCACAGGCGCTGGGGATCA
AGCAGCCGACGGTCGCCGGGATGGAAAAACCGGGGCGTGATGTCAAATTATCCACGCTGAGACGCTATGTGGACGCCATC
GGCGGAAAACTGAATATTGATGTTGAGCTGCCGGACGGCACGCATTATATGTTCAGGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References