Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84084..85707 Replicon plasmid pSI67-1
Accession NZ_CP050784
Organism Salmonella enterica subsp. enterica serovar Indiana strain SI67

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag HEC76_RS23550 Protein ID WP_000088046.1
Coordinates 84382..85707 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag HEC76_RS23545 Protein ID WP_024136327.1
Coordinates 84084..84377 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC76_RS23520 79956..81197 + 1242 WP_001053338.1 VWA domain-containing protein -
HEC76_RS23525 81760..82041 - 282 WP_000077926.1 hypothetical protein -
HEC76_RS23530 82091..82282 - 192 WP_000398480.1 hypothetical protein -
HEC76_RS23535 82374..82715 - 342 WP_001151575.1 hypothetical protein -
HEC76_RS23540 83088..83480 + 393 WP_000341066.1 hypothetical protein -
HEC76_RS23545 84084..84377 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
HEC76_RS23550 84382..85707 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
HEC76_RS23555 85768..85974 + 207 WP_000134171.1 hypothetical protein -
HEC76_RS23560 86076..86486 + 411 WP_000985911.1 hypothetical protein -
HEC76_RS23565 86499..87314 + 816 WP_053276223.1 HNH endonuclease -
HEC76_RS23570 87568..87993 + 426 WP_001043843.1 hypothetical protein -
HEC76_RS23575 88542..88850 + 309 WP_001224687.1 hypothetical protein -
HEC76_RS23580 88866..89723 + 858 WP_000784387.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..255307 255307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 56670.97 Da        Isoelectric Point: 13.4444

>T153170 WP_000088046.1 NZ_CP050784:84382-85707 [Salmonella enterica subsp. enterica serovar Indiana]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 1326 bp

>T153170 NZ_CP066776:c1197285-1196896 [Sulfuriroseicoccus oceanibius]
ATGAACCGCGTCCTCGCCGACACCAACATCTGGTGTGACTTCTTCTCAGGCGGCGACTCCACGCTCGCGCACTTGCTGGA
GTATGATCTCTTGCTCACTCACACTCTGGTCATCGGTGAGCTGGCGGTTGGCAACCTCCCCAAACGGAGACAAACTCTGG
CAGATCTCCAACAACTGCCCCAAATGCGCTCGGCAAGTTTTCACGAAACGCTGACATTCATCAACCACCACCAGCTCTAT
GGTCGTGGTCTACAATGGAATGATCTGCTGATTCTAGCGTCGGTCATTGCCGCCCCCGGAGTCCTGCTCTGGACGCGTGA
CCGTCGCCTTGGCGCGGCTGCCGCCGAGTTCAACGTCGCATTCGACACACCGCAGCATCACAGCAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 12579.08 Da        Isoelectric Point: 12.7867

>AT153170 WP_024136327.1 NZ_CP050784:84084-84377 [Salmonella enterica subsp. enterica serovar Indiana]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKK

Download         Length: 294 bp

>AT153170 NZ_CP066776:c1197524-1197282 [Sulfuriroseicoccus oceanibius]
ATGAGAACCACAGTCACCATTGATGACGAGCTGTTCGCTGAAGCCGCCAAGATCACGGGGGAATCGTCCGCATCGCCTGT
CATCAACGCTGCCCTAAAAGCTCTGGTCGCAGCAGAGAGCCGCAAGCGTCTGCAAGCGCTCGCCGGATCCGCGCCCGGAT
TTACCGTCCCCCCAAGGGACCAGCGCTCCATGCCAATCTGCGTCGCTGATGATCCCCAGAACTACCCGTCTGAGAACCCA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References