Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 222729..223372 Replicon plasmid pSI85-1
Accession NZ_CP050780
Organism Salmonella enterica subsp. enterica serovar Indiana strain SI85

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag HEC77_RS24055 Protein ID WP_001044768.1
Coordinates 222729..223145 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag HEC77_RS24060 Protein ID WP_001261287.1
Coordinates 223142..223372 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC77_RS24040 219228..219818 - 591 WP_000194575.1 hypothetical protein -
HEC77_RS24045 219818..220075 - 258 WP_000343085.1 hypothetical protein -
HEC77_RS24050 220429..222567 + 2139 WP_000350638.1 AAA family ATPase -
HEC77_RS24055 222729..223145 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
HEC77_RS24060 223142..223372 - 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HEC77_RS24065 223668..223958 + 291 WP_000111771.1 hypothetical protein -
HEC77_RS24070 223948..224847 + 900 WP_000963206.1 nucleotide-binding protein -
HEC77_RS24075 224897..227122 - 2226 WP_000698737.1 phage T7 exclusion protein -
HEC77_RS24080 227124..228212 - 1089 WP_000952217.1 transcriptional repressor PifC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR / blaCTX-M-65 / aadA5 / armA / aph(3')-IIa / mph(A) - 1..239058 239058


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T153169 WP_001044768.1 NZ_CP050780:c223145-222729 [Salmonella enterica subsp. enterica serovar Indiana]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T153169 NZ_CP066776:c66760-66500 [Sulfuriroseicoccus oceanibius]
ATGTACAACATGAAGGCGGTCACTTACTCTCACGCTCGCGCGCACCTCGCTCGTACCATCTCAGAAGTTTGTGAGAATCA
TGACCCTGTGGTTATCACCAAGAAGGGGACCGATTCGGTCGTGATGATGTCGTTGGAAGATTACGAATCCATGCAGGAAA
CGGCGTACCTGCTGCGGAGTCCGAAGAATGCCTCGCGACTGCTTCTCTCGCTCGAGCAGCTGGAATCAGGCAAAGGTAAG
GAGCGGCCGCTGGCGAAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT153169 WP_001261287.1 NZ_CP050780:c223372-223142 [Salmonella enterica subsp. enterica serovar Indiana]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT153169 NZ_CP066776:c66503-66249 [Sulfuriroseicoccus oceanibius]
ATGAGGAAGGTTTTCTCGGACCAAGCGTGGGAGGATTACCTCCACTGGCAGAAGACCGACAAGCGCATGTTGCGGAAGGT
TAATGATTTGATCAAAGATATCGACCGGAACCTTCATGAAGGGATAGGGAAGCCCGAACCCTTAAAGCATAGGTTGGCCG
GGTATTGGTCTAGACGGATCAATGCGGAGCATCGTCTCGTGTATCGAATCGACGAGGGCGAGATACAGATCGCCCAGATT
CGCTATCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References