Detailed information of TA system TA153168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 204886..205408
• Replicon: plasmid pSI85-1
• Accession: NZ_CP050780
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain SI85

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D0QMR1
• Locus tag: HEC77_RS23960
• Protein ID: WP_000220561.1
• Coordinates: 205127..205408 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: HEC77_RS23955
• Protein ID: WP_000121743.1
• Coordinates: 204886..205137 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEC77_RS23930	199965..200669	+	705	WP_001067858.1	IS6-like element IS26 family transposase	-
HEC77_RS23935	200699..201403	+	705	WP_032193599.1	replication initiation protein	-
HEC77_RS23940	201997..202800	-	804	Protein_215	glutathione synthase	-
HEC77_RS23945	202865..203128	+	264	Protein_216	IS6 family transposase	-
HEC77_RS23950	203193..203897	+	705	WP_001067858.1	IS6-like element IS26 family transposase	-
HEC77_RS23955	204886..205137	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
HEC77_RS23960	205127..205408	+	282	WP_000220561.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HEC77_RS23965	205647..205739	-	93	Protein_220	IS6 family transposase	-
HEC77_RS23970	205905..207104	-	1200	WP_000948429.1	IS91 family transposase	-
HEC77_RS23975	207114..207302	-	189	WP_000957857.1	hypothetical protein	-
HEC77_RS23980	207422..208852	+	1431	Protein_223	IS4-like element IS50R family transposase	-
HEC77_RS23985	208881..209675	+	795	WP_000572405.1	aminoglycoside O-phosphotransferase APH(3')-IIa	-
HEC77_RS23990	209696..209932	+	237	Protein_225	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	tet(A) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR / blaCTX-M-65 / aadA5 / armA / aph(3')-IIa / mph(A)	-	1..239058	239058

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11023.86 Da
• Isoelectric Point: 10.5938

>T153168 WP_000220561.1 NZ_CP050780:205127-205408 [Salmonella enterica subsp. enterica serovar Indiana]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Nucleotide

• Length: 282 bp

>T153168 NZ_CP066776:c66503-66249 [Sulfuriroseicoccus oceanibius]
ATGAGGAAGGTTTTCTCGGACCAAGCGTGGGAGGATTACCTCCACTGGCAGAAGACCGACAAGCGCATGTTGCGGAAGGT
TAATGATTTGATCAAAGATATCGACCGGAACCTTCATGAAGGGATAGGGAAGCCCGAACCCTTAAAGCATAGGTTGGCCG
GGTATTGGTCTAGACGGATCAATGCGGAGCATCGTCTCGTGTATCGAATCGACGAGGGCGAGATACAGATCGCCCAGATT
CGCTATCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9194.43 Da
• Isoelectric Point: 4.1683

>AT153168 WP_000121743.1 NZ_CP050780:204886-205137 [Salmonella enterica subsp. enterica serovar Indiana]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Nucleotide

• Length: 252 bp

>AT153168 NZ_CP066776:c66760-66500 [Sulfuriroseicoccus oceanibius]
ATGTACAACATGAAGGCGGTCACTTACTCTCACGCTCGCGCGCACCTCGCTCGTACCATCTCAGAAGTTTGTGAGAATCA
TGACCCTGTGGTTATCACCAAGAAGGGGACCGATTCGGTCGTGATGATGTCGTTGGAAGATTACGAATCCATGCAGGAAA
CGGCGTACCTGCTGCGGAGTCCGAAGAATGCCTCGCGACTGCTTCTCTCGCTCGAGCAGCTGGAATCAGGCAAAGGTAAG
GAGCGGCCGCTGGCGAAATGA

Structures

Toxin

• AlphaFold DB: A0A3S5I302

Antitoxin

• AlphaFold DB: A0A3S5I301