Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 116644..118267 | Replicon | plasmid pSI85-1 |
| Accession | NZ_CP050780 | ||
| Organism | Salmonella enterica subsp. enterica serovar Indiana strain SI85 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | H9TH67 |
| Locus tag | HEC77_RS23445 | Protein ID | WP_000088046.1 |
| Coordinates | 116644..117969 (-) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
| Locus tag | HEC77_RS23450 | Protein ID | WP_024136327.1 |
| Coordinates | 117974..118267 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HEC77_RS23415 | 113310..113609 | - | 300 | WP_001572440.1 | hypothetical protein | - |
| HEC77_RS23420 | 113664..113900 | - | 237 | Protein_114 | hypothetical protein | - |
| HEC77_RS23425 | 114358..114783 | - | 426 | WP_001043843.1 | hypothetical protein | - |
| HEC77_RS23430 | 115037..115852 | - | 816 | WP_001572439.1 | HNH endonuclease | - |
| HEC77_RS23435 | 115865..116275 | - | 411 | WP_000985911.1 | hypothetical protein | - |
| HEC77_RS23440 | 116377..116583 | - | 207 | WP_000134171.1 | hypothetical protein | - |
| HEC77_RS23445 | 116644..117969 | - | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| HEC77_RS23450 | 117974..118267 | - | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HEC77_RS23455 | 118567..119271 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HEC77_RS23460 | 119389..119592 | - | 204 | WP_000376616.1 | hypothetical protein | - |
| HEC77_RS23465 | 119720..120559 | - | 840 | WP_000259031.1 | sulfonamide-resistant dihydropteroate synthase Sul1 | - |
| HEC77_RS23470 | 120553..120900 | - | 348 | WP_000679427.1 | quaternary ammonium compound efflux SMR transporter QacE delta 1 | - |
| HEC77_RS23475 | 121123..121575 | - | 453 | WP_001749986.1 | NAD(+)--rifampin ADP-ribosyltransferase Arr-3 | - |
| HEC77_RS23480 | 121660..122292 | - | 633 | WP_000186237.1 | type B-3 chloramphenicol O-acetyltransferase CatB3 | - |
| HEC77_RS23485 | 122430..123260 | - | 831 | WP_001334766.1 | oxacillin-hydrolyzing class D beta-lactamase OXA-1 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(A) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR / blaCTX-M-65 / aadA5 / armA / aph(3')-IIa / mph(A) | - | 1..239058 | 239058 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T153167 WP_000088046.1 NZ_CP050780:c117969-116644 [Salmonella enterica subsp. enterica serovar Indiana]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
>T153167 NZ_CP066775:652385-652582 [Mucilaginibacter ginkgonis]
ATGCCCAAGCAAAGCTATAGCTCCAGGGAAATAATAAAATTACTGGAAGACGGTGGTTTTATACTCGACCAGGTTAAAGG
AAGCCACCATATTTACTATCATCCGGTTGATAAAAAGCGTGCGGTTGTGCCCCATCCTAAAAAAGAGCTGCCATATGGTA
CGGCGCGTAGCATACTTAAACAAGCCGGCTTTCTATAG
ATGCCCAAGCAAAGCTATAGCTCCAGGGAAATAATAAAATTACTGGAAGACGGTGGTTTTATACTCGACCAGGTTAAAGG
AAGCCACCATATTTACTATCATCCGGTTGATAAAAAGCGTGCGGTTGTGCCCCATCCTAAAAAAGAGCTGCCATATGGTA
CGGCGCGTAGCATACTTAAACAAGCCGGCTTTCTATAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT153167 WP_024136327.1 NZ_CP050780:c118267-117974 [Salmonella enterica subsp. enterica serovar Indiana]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
>AT153167 NZ_CP066775:652187-652384 [Mucilaginibacter ginkgonis]
TTGAAACCAGAACCAGAGGGTGGCTTCACGGTTAATGTGCCGGCCTTGCCCGGTTGCATAAGTTATGGTGAAACACTTGA
AGAGGCGAGAACTAATGCCCAGGAAGCGATAGAACTATATATTGAAAGTCTACGAGCCCATGGCGAAGAGATTCCTTCAG
ACGAAAACGTGCTGGAATATAATATCCAGCTGTCTTAA
TTGAAACCAGAACCAGAGGGTGGCTTCACGGTTAATGTGCCGGCCTTGCCCGGTTGCATAAGTTATGGTGAAACACTTGA
AGAGGCGAGAACTAATGCCCAGGAAGCGATAGAACTATATATTGAAAGTCTACGAGCCCATGGCGAAGAGATTCCTTCAG
ACGAAAACGTGCTGGAATATAATATCCAGCTGTCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T0VBU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z6V2D1 |