Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 152116..153739 Replicon plasmid pSI96-1
Accession NZ_CP050778
Organism Salmonella enterica subsp. enterica serovar Indiana strain SI96

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag HEC78_RS23965 Protein ID WP_000088046.1
Coordinates 152116..153441 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag HEC78_RS23970 Protein ID WP_024136327.1
Coordinates 153446..153739 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC78_RS23935 148100..148957 - 858 WP_000784387.1 HNH endonuclease -
HEC78_RS23940 148973..149281 - 309 WP_001224687.1 hypothetical protein -
HEC78_RS23945 149830..150255 - 426 WP_001043843.1 hypothetical protein -
HEC78_RS23950 150509..151324 - 816 WP_053276223.1 HNH endonuclease -
HEC78_RS23955 151337..151747 - 411 WP_000985911.1 hypothetical protein -
HEC78_RS23960 151849..152055 - 207 WP_062914745.1 hypothetical protein -
HEC78_RS23965 152116..153441 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
HEC78_RS23970 153446..153739 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
HEC78_RS23975 154343..154735 - 393 WP_000341066.1 hypothetical protein -
HEC78_RS23980 155108..155449 + 342 WP_001151575.1 hypothetical protein -
HEC78_RS23985 155541..155732 + 192 WP_000398480.1 hypothetical protein -
HEC78_RS23990 155782..156063 + 282 WP_000077926.1 hypothetical protein -
HEC78_RS23995 156626..157867 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..190811 190811


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-72)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-90)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 65070.07 Da        Isoelectric Point: 5.5500

>T153166 WP_000088046.1 NZ_CP050778:c153441-152116 [Salmonella enterica subsp. enterica serovar Indiana]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 1326 bp

>T153166 NZ_CP066774:c7299919-7299662 [Streptomyces murinus]
GTGGAAGAACAGTGGGACGTCTACCTGACCGCCGAGGTGGATCAGTGGCTGCACGATCTCAAGGAGTTGCGTCCCGGCTC
GACGGGACGAAGTGAAGTGCGCGTCCTGTTCATGTTCGACCCCTGGCGCTCCGCGATTCTTCTGACGGCCGGGGACAAGG
CGGGGGACTGGGGTGCCTGGTACGAGCGGGCGATCCCCCTGGCCGAGCGGGCCTATACGGAGTACCTGGCCGATCGGGAG
AAGGAGTCGGGGAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 14441.32 Da        Isoelectric Point: 5.5500

>AT153166 WP_024136327.1 NZ_CP050778:c153739-153446 [Salmonella enterica subsp. enterica serovar Indiana]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFF

Download         Length: 294 bp

>AT153166 NZ_CP066774:c7299665-7299342 [Streptomyces murinus]
ATGAGCGGATACACCAAGTGGTCCGGAAGCGGTCACCGTGAACGCGCGGAAGAGCTGGCCGGAGGGCGGGAGCCGTTTTT
CGCCGGGGCGGAACGGCTGCTCGCGCAGGCGCGGGCCTGGCGGTTGGTGGAGATGAGGCAGGAGCGGGGCTTCACTCAGG
CTCAGGTCGCCGAGCGCATGGGCGTGAGCAAGGGGCGGGTCTCGCAGATCGAGAGTGGGCAGGTGTCCGGGACGGAGGTC
GTCGCCCGGTACGTCGAGGCGTTGGGCGGAAACCTGGTGATGGTCGCGGTGTTCGCGGACGGGGAACTGCGCAAGGTCGG
ATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References