Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 85402..87025 Replicon plasmid pSI170-1
Accession NZ_CP050761
Organism Salmonella enterica subsp. enterica serovar Indiana strain SI170

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag HEC83_RS23560 Protein ID WP_000088046.1
Coordinates 85700..87025 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag HEC83_RS23555 Protein ID WP_024136327.1
Coordinates 85402..85695 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC83_RS23530 81274..82515 + 1242 WP_001053338.1 VWA domain-containing protein -
HEC83_RS23535 83078..83359 - 282 WP_000077926.1 hypothetical protein -
HEC83_RS23540 83409..83600 - 192 WP_000398480.1 hypothetical protein -
HEC83_RS23545 83692..84033 - 342 WP_001151575.1 hypothetical protein -
HEC83_RS23550 84406..84798 + 393 WP_000341066.1 hypothetical protein -
HEC83_RS23555 85402..85695 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
HEC83_RS23560 85700..87025 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
HEC83_RS23565 87086..87292 + 207 WP_000134171.1 hypothetical protein -
HEC83_RS23570 87394..87804 + 411 WP_000985911.1 hypothetical protein -
HEC83_RS23575 87817..88632 + 816 WP_053276223.1 HNH endonuclease -
HEC83_RS23580 88886..89311 + 426 WP_001043843.1 hypothetical protein -
HEC83_RS23585 89860..90168 + 309 WP_001224687.1 hypothetical protein -
HEC83_RS23590 90184..91041 + 858 WP_000784387.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..214820 214820


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(20-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 56670.97 Da        Isoelectric Point: 13.4444

>T153158 WP_000088046.1 NZ_CP050761:85700-87025 [Salmonella enterica subsp. enterica serovar Indiana]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 1326 bp

>T153158 NZ_CP066770:c684858-684520 [Burkholderia anthina]
CTGGCTACTGCGTATGAGATTCAGTTCTTCAATGCGCGCGTAGAAACGGGCGTTATCACGTTACCGAAGACACTGCTCGC
CCGTTTTTTCGCGCTCGCCGACCGCATGGAGCAGTACGGCCCGAACCTCCGCGAGCCGCACACCCAGTCGATGGGCAACG
GGCTGTACGAAATGCGACTCAAGGGCGCCGAAGGCATCGCCAGAGTGTTCTACTGCGCGATCGTCGACCGGCGTATCGTC
ATGCTTCATTGTTTCGTGAAGAAGACGCAAAAGACGCCACGGAAAAAACTGGAAACCGCGCGCCGCCGACTGAAGGAGGT
TCAAGATGGCAACGTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 12579.08 Da        Isoelectric Point: 12.7867

>AT153158 WP_024136327.1 NZ_CP050761:85402-85695 [Salmonella enterica subsp. enterica serovar Indiana]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKK

Download         Length: 294 bp

>AT153158 NZ_CP066770:c684533-684246 [Burkholderia anthina]
ATGGCAACGTATAAGGCACTGCGCGAGCGCGCTTTGTCCGACCCCGAGGTGCACGCCGAATACGAACGACTGAACCGCGA
AGACCTCACACTGCTCGACGCGATGCTGGCTGCGCGGCGCGACGCCGGGCTGTCGCAAGCCGATGTGGCCAAGCGCATGG
GCACGAAGGCACCGGCGGTGACGCGCCTCGAGCGCGCGCTCGCAACGGGCCAGCATTCACCGTCCATCGATACGTTGCGC
AAGTACGCAACCGCTTGCGGCAAGAAACTCGTGATCTCGTTCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References