Detailed information of TA system TA153157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1981..2540
• Replicon: plasmid pSI173-1
• Accession: NZ_CP050758
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain SI173

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U9YB49
• Locus tag: HEC84_RS22665
• Protein ID: WP_000421259.1
• Coordinates: 2265..2540 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U9Y625
• Locus tag: HEC84_RS22660
• Protein ID: WP_001178087.1
• Coordinates: 1981..2265 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEC84_RS22655	46..1077	+	1032	WP_000907852.1	replication initiation protein	-
HEC84_RS22660	1981..2265	+	285	WP_001178087.1	ribbon-helix-helix protein, CopG family	Antitoxin
HEC84_RS22665	2265..2540	+	276	WP_000421259.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HEC84_RS22670	2646..2927	+	282	WP_001105066.1	hypothetical protein	-
HEC84_RS23380	3119..3385	-	267	WP_000627832.1	hypothetical protein	-
HEC84_RS22675	3385..3879	-	495	WP_015058884.1	hypothetical protein	-
HEC84_RS22680	3935..4537	-	603	WP_000517694.1	hypothetical protein	-
HEC84_RS22685	4891..6237	+	1347	WP_001132032.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..87883	87883

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-126)

Antitoxin

• SpoVT-AbrB domain (7-38)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11810.03 Da
• Isoelectric Point: 12.7590

>T153157 WP_000421259.1 NZ_CP050758:2265-2540 [Salmonella enterica subsp. enterica serovar Indiana]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKK

Nucleotide

• Length: 276 bp

>T153157 NZ_CP066769:1786466-1786888 [Burkholderia anthina]
GTGACGACGCTCTACATGCTCGATACGAACATCCGTTCGTTCATCATGCGCGAGCGGCCGCCCGTGGCGTTGTCCCGGCT
GCAGTCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCGATCACCTATGCCGAAATGCGATTCGGCGCCGTGGGCA
AGAAGGCATCGCCCAGGCATGCGGAACTCGTGACGGCCTTCGTCGCAAGGCTGGACGGCGTGCTGTCGTGGGATACGGCC
GCAGTCGACGCAACGACCGCGGTTCGAGCCGGGCTCGCGGCACGCGGCACGCCGATCGGCGCAAACGATGCGTCGATCGC
CGGCCATGCGATTGCCGCCGGCGCGGTGCTCGTGACGAATAACAGTCGTGAATTCAGTTGCGTCGCGGGGTTGTCCGTCG
AAGACTGGGCAATGTCGGCCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 12194.55 Da
• Isoelectric Point: 12.7731

>AT153157 WP_001178087.1 NZ_CP050758:1981-2265 [Salmonella enterica subsp. enterica serovar Indiana]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKK

Nucleotide

• Length: 285 bp

>AT153157 NZ_CP066769:1786206-1786469 [Burkholderia anthina]
ATGCGCACCGTTTCCATTTTCAAGACCGCCCGTAACCAGGCAATCCGTATCCCGAAGGACATGGAATTCGAGGGCGTAAC
CGAGCTCGAGATCCGCCGCGAGGGCGATACGCTGCTGCGTCCGGGGCGACCGACATGGCTGTCGTTCGCGAACGAACCTC
TGGCCGATTCCGACTTCCTCATCGAGCGCCCGGCCGTCGTCGAAACCGGCCGTTTCGACCTGTCCGGCGCCGATCACGAC
GCCTCGCCGGAGTCGGGCCAGTGA

Structures

Toxin

• AlphaFold DB: U9YB49

Antitoxin

• AlphaFold DB: U9Y625