Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84084..85707 Replicon plasmid pST46-1
Accession NZ_CP050751
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ST46

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag HEC87_RS24775 Protein ID WP_000088046.1
Coordinates 84382..85707 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag HEC87_RS24770 Protein ID WP_024136327.1
Coordinates 84084..84377 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC87_RS24745 79956..81197 + 1242 WP_001053338.1 VWA domain-containing protein -
HEC87_RS24750 81760..82041 - 282 WP_000077926.1 hypothetical protein -
HEC87_RS24755 82091..82282 - 192 WP_000398480.1 hypothetical protein -
HEC87_RS24760 82374..82715 - 342 WP_001151575.1 hypothetical protein -
HEC87_RS24765 83088..83480 + 393 WP_000341066.1 hypothetical protein -
HEC87_RS24770 84084..84377 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
HEC87_RS24775 84382..85707 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
HEC87_RS24780 85768..85974 + 207 WP_000134171.1 hypothetical protein -
HEC87_RS24785 86076..86486 + 411 WP_000985911.1 hypothetical protein -
HEC87_RS24790 86499..87314 + 816 WP_001572439.1 HNH endonuclease -
HEC87_RS24795 87568..87993 + 426 WP_001043843.1 hypothetical protein -
HEC87_RS24800 88447..88683 + 237 Protein_85 hypothetical protein -
HEC87_RS24805 88738..89037 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / floR / aph(6)-Id / aph(3'')-Ib / sul2 / aph(4)-Ia / aac(3)-IVa / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aph(3')-Ia / dfrA12 / oqxA / oqxB / catA2 / blaCTX-M-55 - 1..260225 260225


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T153147 WP_000088046.1 NZ_CP050751:84382-85707 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T153147 NZ_CP066763:c92112-91531 [Burkholderia ambifaria]
ATGAACCTCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
CACGTCGACGGGCCGCCGCGAAAGCACGGCGGAGCACAGCTGGCGACTGTGCCTGATGGCGCTCGTGTTCGCCGATGCGC
TGCCCGACGTCGACACGACGAAGCTGCTGAAACTGTGCGTCGTCCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAACAGGCCGCGCATCCGGACAAGAGCACGCACGAACGCGACGATCTGCTGACGCTGACGGCCGGCCTCGATCG
CGCGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGAATCGCCGGAAGCGCGCGCCGCGAAAGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGGCGGCGCTACACCGACGCGACGCCGCTGTTCGACGCGATCCGCGCGATCGTCGACGCGGACACGCAACGCAGGATCGA
CGCACGCGGCGACGGCGCGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT153147 WP_024136327.1 NZ_CP050751:84084-84377 [Salmonella enterica subsp. enterica serovar Typhimurium]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT153147 NZ_CP066763:c92778-92221 [Burkholderia ambifaria]
ATGACGACCTCGCCGCTTCACACCCCGCCGCTCGGCCCGCAACTCAAGCGCTGGCGCACGCTGCGCCGCGTGAAGCAGAG
CCATGCGGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTTGCCGCGCGTCTCGATTCGGCCGGCGACCACGCGCTCGCGCGGCTGATCGCGAGC
AGCACGGCCCGCATGCATCTCGTGTGCGACCTCACGCACCGTCTGCTCGCCTGCTCGCCGGCGCGCGCGGCCGAGTTCTC
GCGGCCGCTGCCGGCGTTGCTCGGTACCTCGCTGTGGCGCTATGCGTCACCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ATCCGCTCGGCTGGCACGATCGCGCGGGGCCGCCGAGCGTCGAATTCGCGACCGGGACCAATGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCACCTGCCGGTGGACGCGAATGACGCTATCGGACGGCTCCGCCGCGCGGCTCGTCGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References