Detailed information of TA system TA153146

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 57764..58389
• Replicon: plasmid pST90-2
• Accession: NZ_CP050736
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain ST90

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HEC90_RS25115
• Protein ID: WP_000911322.1
• Coordinates: 57764..58162 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HEC90_RS25120
• Protein ID: WP_000450265.1
• Coordinates: 58162..58389 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEC90_RS25100	53892..54386	+	495	WP_010999946.1	entry exclusion protein	-
HEC90_RS25105	54422..55153	+	732	WP_000782438.1	complement resistance protein TraT	-
HEC90_RS25110	55530..57755	+	2226	WP_080218652.1	type IV conjugative transfer system coupling protein TraD	-
HEC90_RS25115	57764..58162	-	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
HEC90_RS25120	58162..58389	-	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..110163	110163

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 19592.50 Da
• Isoelectric Point: 5.5500

>T153146 WP_000911322.1 NZ_CP050736:c58162-57764 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 399 bp

>T153146 NZ_CP066762:1712748-1713170 [Burkholderia ambifaria]
GTGACGACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCAGCCGCGGTGTTGTCCCGGTT
GCAGTCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCGATCACCTATGCCGAGATGCGGTTCGGCGCAGTCGGCA
GAAAGGCTTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTTTCGCGGCTGGATGGCGTGCTGTCGTGGGATACCGCG
GCGGTCGATGCAACGACCGCGATTCGCGTCGACCTTGCCGCACGTGGCACGCCGATCGGCGCAAACGACGCGTCGATCGC
CGGTCATGCGATCGCGGCCGGTGCCGTGCTTGTAACGAACAACAGTCGCGAATTCAGCCGTGTCGCGGGGTTGTCGCTCG
AAGATTGGGCAGCCTCGGCCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 11203.44 Da
• Isoelectric Point: 5.5500

>AT153146 WP_000450265.1 NZ_CP050736:c58389-58162 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 228 bp

>AT153146 NZ_CP066762:1712485-1712751 [Burkholderia ambifaria]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGTGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACGTTGCTGCTGCGTCCGGTGCGGCCGACGTGGCTGTCGTTCGCGACTGAAC
CACGGGCCGATGCCGACTTCCTCGTCGAGCGCCCGACGGTGGTCGAAGCCGGTCGTTTCGAGCTGCCCGGCGCCGATGAC
GATGTACCGACGGAGTCGGCCCGGTGA