Detailed information of TA system TA153142

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 6550..7109
• Replicon: plasmid pST90-1
• Accession: NZ_CP050735
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain ST90

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V0SVC8
• Locus tag: HEC90_RS23925
• Protein ID: WP_000421272.1
• Coordinates: 6550..6825 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V0SRR3
• Locus tag: HEC90_RS23930
• Protein ID: WP_001387467.1
• Coordinates: 6825..7109 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HEC90_RS23895	2124..2306	-	183	WP_042344623.1	hypothetical protein	-
HEC90_RS23900	2649..2956	-	308	Protein_3	type II toxin-antitoxin system ParD family antitoxin	-
HEC90_RS23905	3078..4306	+	1229	WP_113708090.1	IS3-like element IS2 family transposase	-
HEC90_RS23910	4785..5955	+	1171	Protein_5	hypothetical protein	-
HEC90_RS23915	5988..6116	+	129	Protein_6	IS481 family transposase	-
HEC90_RS23920	6151..6444	-	294	WP_001105060.1	hypothetical protein	-
HEC90_RS23925	6550..6825	-	276	WP_000421272.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HEC90_RS23930	6825..7109	-	285	WP_001387467.1	ribbon-helix-helix protein, CopG family	Antitoxin
HEC90_RS23935	7714..8466	+	753	WP_000562172.1	IclR family transcriptional regulator	-
HEC90_RS23940	8512..8781	-	270	Protein_11	2-keto-3-deoxygluconate permease	-
HEC90_RS23945	8842..9546	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-
HEC90_RS23950	9599..9835	-	237	Protein_13	DUF3330 domain-containing protein	-
HEC90_RS23955	10038..11051	-	1014	WP_000845048.1	class 1 integron integrase IntI1	-
HEC90_RS23960	11200..11991	+	792	WP_032491824.1	ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA22	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..150326	150326

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (14-51)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 13558.26 Da
• Isoelectric Point: 5.5500

>T153142 WP_000421272.1 NZ_CP050735:c6825-6550 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFF

Nucleotide

• Length: 276 bp

>T153142 NZ_CP066760:54960-55235 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 13999.79 Da
• Isoelectric Point: 5.5500

>AT153142 WP_001387467.1 NZ_CP050735:c7109-6825 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFF

Nucleotide

• Length: 285 bp

>AT153142 NZ_CP066760:54676-54960 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Structures

Toxin

• AlphaFold DB: V0SVC8

Antitoxin

• AlphaFold DB: A0A0E0Y880