Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 42888..43410 Replicon plasmid pSE74-1
Accession NZ_CP050724
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE74

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag HEC94_RS22865 Protein ID WP_000220561.1
Coordinates 43129..43410 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HEC94_RS22860 Protein ID WP_000121743.1
Coordinates 42888..43139 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC94_RS22840 39011..39433 - 423 WP_179292036.1 DNA distortion polypeptide 3 -
HEC94_RS22845 39501..39947 - 447 WP_001074384.1 hypothetical protein -
HEC94_RS22850 39951..40793 - 843 WP_000435064.1 replication initiation protein -
HEC94_RS22855 40814..41653 - 840 WP_024129959.1 replication initiation protein -
HEC94_RS22860 42888..43139 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HEC94_RS22865 43129..43410 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HEC94_RS22870 43649..43741 - 93 Protein_50 IS6 family transposase -
HEC94_RS22875 43907..45106 - 1200 WP_072648941.1 IS91 family transposase -
HEC94_RS22880 45116..45304 - 189 WP_000957857.1 hypothetical protein -
HEC94_RS22885 45424..46854 + 1431 Protein_53 IS4-like element IS50R family transposase -
HEC94_RS22890 46883..47677 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
HEC94_RS22895 47698..47934 + 237 Protein_55 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..115154 115154


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T153138 WP_000220561.1 NZ_CP050724:43129-43410 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T153138 NZ_CP066759:c4869003-4868653 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT153138 WP_000121743.1 NZ_CP050724:42888-43139 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT153138 NZ_CP066759:c4869248-4868997 [Escherichia coli O157:H7]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References