Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 34373..34895 Replicon plasmid pSE104-1
Accession NZ_CP050713
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE104

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag HEC97_RS22840 Protein ID WP_000220561.1
Coordinates 34614..34895 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HEC97_RS22835 Protein ID WP_000121743.1
Coordinates 34373..34624 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC97_RS22815 30496..30918 - 423 WP_179292036.1 DNA distortion polypeptide 3 -
HEC97_RS22820 30986..31432 - 447 WP_001074384.1 hypothetical protein -
HEC97_RS22825 31436..32278 - 843 WP_000435064.1 replication initiation protein -
HEC97_RS22830 32299..33138 - 840 WP_024129959.1 replication initiation protein -
HEC97_RS22835 34373..34624 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HEC97_RS22840 34614..34895 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HEC97_RS22845 35134..35226 - 93 Protein_42 IS6 family transposase -
HEC97_RS22850 35392..36591 - 1200 WP_072648941.1 IS91 family transposase -
HEC97_RS22855 36601..36789 - 189 WP_000957857.1 hypothetical protein -
HEC97_RS22860 37019..37123 + 105 WP_032409716.1 hypothetical protein -
HEC97_RS22865 37252..37509 + 258 WP_000764642.1 hypothetical protein -
HEC97_RS22870 37567..38343 - 777 WP_000015958.1 site-specific integrase -
HEC97_RS22875 38340..39083 - 744 WP_000129823.1 hypothetical protein -
HEC97_RS22880 39134..39484 - 351 WP_000493378.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..106652 106652


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T153135 WP_000220561.1 NZ_CP050713:34614-34895 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T153135 NZ_CP066759:4390535-4390795 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT153135 WP_000121743.1 NZ_CP050713:34373-34624 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT153135 NZ_CP066759:4390256-4390516 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References