Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 14141..14663 | Replicon | plasmid pSE109-1 |
| Accession | NZ_CP050710 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain SE109 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D0QMR1 |
| Locus tag | HEC98_RS22730 | Protein ID | WP_000220561.1 |
| Coordinates | 14141..14422 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G3CAG1 |
| Locus tag | HEC98_RS22735 | Protein ID | WP_000121743.1 |
| Coordinates | 14412..14663 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HEC98_RS22685 | 9221..9925 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HEC98_RS22690 | 9991..10536 | + | 546 | Protein_13 | Tn3 family transposase | - |
| HEC98_RS22695 | 10572..10987 | - | 416 | Protein_14 | IS1 family transposase | - |
| HEC98_RS22700 | 11236..11637 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| HEC98_RS22705 | 11570..11827 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| HEC98_RS22710 | 11920..12129 | - | 210 | Protein_17 | CPBP family intramembrane metalloprotease | - |
| HEC98_RS22715 | 12247..12435 | + | 189 | WP_000957857.1 | hypothetical protein | - |
| HEC98_RS22720 | 12445..13644 | + | 1200 | WP_072648941.1 | IS91 family transposase | - |
| HEC98_RS22725 | 13810..13902 | + | 93 | Protein_20 | IS6 family transposase | - |
| HEC98_RS22730 | 14141..14422 | - | 282 | WP_000220561.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HEC98_RS22735 | 14412..14663 | - | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
| HEC98_RS22740 | 15898..16737 | + | 840 | WP_024129959.1 | replication initiation protein | - |
| HEC98_RS22745 | 16758..17600 | + | 843 | WP_000435064.1 | replication initiation protein | - |
| HEC98_RS22750 | 17604..18050 | + | 447 | WP_001074384.1 | hypothetical protein | - |
| HEC98_RS22755 | 18118..18540 | + | 423 | WP_179292036.1 | DNA distortion polypeptide 3 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..90315 | 90315 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 13852.62 Da Isoelectric Point: 5.5500
>T153134 WP_000220561.1 NZ_CP050710:c14422-14141 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF
Download Length: 282 bp
>T153134 NZ_CP066759:c4384536-4384138 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 12380.85 Da Isoelectric Point: 5.5500
>AT153134 WP_000121743.1 NZ_CP050710:c14663-14412 [Salmonella enterica subsp. enterica serovar Enteritidis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF
Download Length: 252 bp
>AT153134 NZ_CP066759:c4384832-4384539 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S5I302 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S5I301 |