Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 15570..16092 Replicon plasmid pSE124-1
Accession NZ_CP050707
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE124

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag HEC99_RS22715 Protein ID WP_000220561.1
Coordinates 15811..16092 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HEC99_RS22710 Protein ID WP_000121743.1
Coordinates 15570..15821 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC99_RS22690 11693..12115 - 423 WP_179292036.1 DNA distortion polypeptide 3 -
HEC99_RS22695 12183..12629 - 447 WP_001074384.1 hypothetical protein -
HEC99_RS22700 12633..13475 - 843 WP_000435064.1 replication initiation protein -
HEC99_RS22705 13496..14335 - 840 WP_024129959.1 replication initiation protein -
HEC99_RS22710 15570..15821 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HEC99_RS22715 15811..16092 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HEC99_RS22720 16331..16423 - 93 Protein_20 IS6 family transposase -
HEC99_RS22725 16589..17788 - 1200 WP_072648941.1 IS91 family transposase -
HEC99_RS22730 17798..17986 - 189 WP_000957857.1 hypothetical protein -
HEC99_RS22735 18106..19536 + 1431 Protein_23 IS4-like element IS50R family transposase -
HEC99_RS22740 19565..20359 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
HEC99_RS22745 20380..20616 + 237 Protein_25 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..108447 108447


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T153133 WP_000220561.1 NZ_CP050707:15811-16092 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T153133 NZ_CP066759:4089591-4089809 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT153133 WP_000121743.1 NZ_CP050707:15570-15821 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT153133 NZ_CP066759:4089191-4089565 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References