Detailed information of TA system TA153128

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2589914..2590545
• Replicon: chromosome
• Accession: NZ_CP050695
• Organism: Aquisalimonas sp. 2447

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HC341_RS12120
• Protein ID: WP_167782885.1
• Coordinates: 2590144..2590545 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HC341_RS12115
• Protein ID: WP_167782884.1
• Coordinates: 2589914..2590144 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC341_RS12095	2585812..2586078	+	267	WP_167782241.1	transposase	-
HC341_RS12100	2586706..2586981	-	276	WP_167782881.1	hypothetical protein	-
HC341_RS12105	2587200..2588447	-	1248	WP_167782882.1	site-specific integrase	-
HC341_RS12110	2588592..2588960	-	369	WP_167782883.1	XRE family transcriptional regulator	-
HC341_RS12115	2589914..2590144	+	231	WP_167782884.1	antitoxin	Antitoxin
HC341_RS12120	2590144..2590545	+	402	WP_167782885.1	tRNA(fMet)-specific endonuclease VapC	Toxin
HC341_RS12125	2590559..2590933	-	375	WP_167782886.1	hypothetical protein	-
HC341_RS12130	2590950..2591372	-	423	WP_167782887.1	antitoxin	-
HC341_RS12135	2591656..2592048	-	393	WP_167782888.1	hypothetical protein	-
HC341_RS12140	2592236..2592484	+	249	WP_167782889.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
HC341_RS12145	2592484..2592906	+	423	WP_167782890.1	type II toxin-antitoxin system VapC family toxin	-
HC341_RS12150	2593378..2594883	-	1506	WP_167782891.1	IS1380 family transposase	-
HC341_RS12155	2595055..2595321	+	267	WP_167784237.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2562594..2595913	33319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14641.80 Da
• Isoelectric Point: 6.7192

>T153128 WP_167782885.1 NZ_CP050695:2590144-2590545 [Aquisalimonas sp. 2447]
MLKYMLDTNIAIYTIKNRPPEVREALKAHDGQMCISAVTLMELIYGAEASAAVDRNLKDVEGFAARLDVLPYDNDAAAHT
GQLRAELKKIGRPIGAYDEMISGHARSQGLVVVSNNTKQFENVPGIRVINWVS

Nucleotide

• Length: 402 bp

>T153128 NZ_CP066759:2914241-2914348 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8635.71 Da
• Isoelectric Point: 4.5556

>AT153128 WP_167782884.1 NZ_CP050695:2589914-2590144 [Aquisalimonas sp. 2447]
MERATLFRSNKSQALRLPKPVAYPDAVKQVDIIAQGRTRIIVPAGESWDCWFDGEGVSEDFMASREQPDPQERETL

Nucleotide

• Length: 231 bp

>AT153128 NZ_CP066759:c2914193-2914134 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT