Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2589914..2590545 Replicon chromosome
Accession NZ_CP050695
Organism Aquisalimonas sp. 2447

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HC341_RS12120 Protein ID WP_167782885.1
Coordinates 2590144..2590545 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HC341_RS12115 Protein ID WP_167782884.1
Coordinates 2589914..2590144 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC341_RS12095 2585812..2586078 + 267 WP_167782241.1 transposase -
HC341_RS12100 2586706..2586981 - 276 WP_167782881.1 hypothetical protein -
HC341_RS12105 2587200..2588447 - 1248 WP_167782882.1 site-specific integrase -
HC341_RS12110 2588592..2588960 - 369 WP_167782883.1 XRE family transcriptional regulator -
HC341_RS12115 2589914..2590144 + 231 WP_167782884.1 antitoxin Antitoxin
HC341_RS12120 2590144..2590545 + 402 WP_167782885.1 tRNA(fMet)-specific endonuclease VapC Toxin
HC341_RS12125 2590559..2590933 - 375 WP_167782886.1 hypothetical protein -
HC341_RS12130 2590950..2591372 - 423 WP_167782887.1 antitoxin -
HC341_RS12135 2591656..2592048 - 393 WP_167782888.1 hypothetical protein -
HC341_RS12140 2592236..2592484 + 249 WP_167782889.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
HC341_RS12145 2592484..2592906 + 423 WP_167782890.1 type II toxin-antitoxin system VapC family toxin -
HC341_RS12150 2593378..2594883 - 1506 WP_167782891.1 IS1380 family transposase -
HC341_RS12155 2595055..2595321 + 267 WP_167784237.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2562594..2595913 33319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14641.80 Da        Isoelectric Point: 6.7192

>T153128 WP_167782885.1 NZ_CP050695:2590144-2590545 [Aquisalimonas sp. 2447]
MLKYMLDTNIAIYTIKNRPPEVREALKAHDGQMCISAVTLMELIYGAEASAAVDRNLKDVEGFAARLDVLPYDNDAAAHT
GQLRAELKKIGRPIGAYDEMISGHARSQGLVVVSNNTKQFENVPGIRVINWVS

Download         Length: 402 bp

>T153128 NZ_CP066759:2914241-2914348 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8635.71 Da        Isoelectric Point: 4.5556

>AT153128 WP_167782884.1 NZ_CP050695:2589914-2590144 [Aquisalimonas sp. 2447]
MERATLFRSNKSQALRLPKPVAYPDAVKQVDIIAQGRTRIIVPAGESWDCWFDGEGVSEDFMASREQPDPQERETL

Download         Length: 231 bp

>AT153128 NZ_CP066759:c2914193-2914134 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References