Detailed information of TA system TA153127

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_26
• Location: 2541983..2542614
• Replicon: chromosome
• Accession: NZ_CP050695
• Organism: Aquisalimonas sp. 2447

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HC341_RS11900
• Protein ID: WP_167782850.1
• Coordinates: 2541983..2542243 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HC341_RS11905
• Protein ID: WP_167782851.1
• Coordinates: 2542240..2542614 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC341_RS11885	2537873..2538289	+	417	WP_167782847.1	IS200/IS605 family transposase	-
HC341_RS11890	2538340..2538561	+	222	WP_167782848.1	PIN domain-containing protein	-
HC341_RS11895	2538664..2541903	+	3240	WP_167782849.1	DEAD/DEAH box helicase	-
HC341_RS11900	2541983..2542243	+	261	WP_167782850.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HC341_RS11905	2542240..2542614	+	375	WP_167782851.1	helix-turn-helix transcriptional regulator	Antitoxin
HC341_RS11910	2543019..2544311	-	1293	WP_167782852.1	TolC family outer membrane protein	-
HC341_RS11915	2544559..2545698	+	1140	WP_167782853.1	glycosyltransferase family 4 protein	-
HC341_RS11920	2545701..2546495	+	795	WP_167782854.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2528079..2546495	18416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Cro/C1-type helix-turn-helix domain (68-122)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9949.76 Da
• Isoelectric Point: 11.1955

>T153127 WP_167782850.1 NZ_CP050695:2541983-2542243 [Aquisalimonas sp. 2447]
MHSMRYRKAALKALRRMPAPQARKLVEALSEIAKDPSQPRGSQWKPMKGQEFWRLRQGSYRALCRIDDGELVILVLKVGP
RGDIYK

Nucleotide

• Length: 261 bp

>T153127 NZ_CP066759:2522728-2522904 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13951.63 Da
• Isoelectric Point: 4.2432

>AT153127 WP_167782851.1 NZ_CP050695:2542240-2542614 [Aquisalimonas sp. 2447]
MSVQIIERNGAPEYAVIPYEEYQRLLKQAEEAQDLKDAEEAARAIEQGEETIPLEVVERLLNGADHPIKVWREYRELTQE
ALAEQVGVGKSYISQLESRSRTGSTRVIKALAQALGVDLDDLLE

Nucleotide

• Length: 375 bp

>AT153127 NZ_CP066759:2522950-2523366 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCAGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA