Detailed information of TA system TA153126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2518696..2519624
• Replicon: chromosome
• Accession: NZ_CP050695
• Organism: Aquisalimonas sp. 2447

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HC341_RS11790
• Protein ID: WP_167782833.1
• Coordinates: 2518696..2519181 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HC341_RS11795
• Protein ID: WP_167782834.1
• Coordinates: 2519178..2519624 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC341_RS11765	2513863..2514666	-	804	WP_167782828.1	crotonobetainyl-CoA hydratase	-
HC341_RS11770	2514926..2516005	+	1080	WP_167782829.1	hypothetical protein	-
HC341_RS11775	2516106..2516966	-	861	WP_167782830.1	hypothetical protein	-
HC341_RS11780	2517184..2518224	+	1041	WP_167782831.1	MBL fold metallo-hydrolase	-
HC341_RS11785	2518332..2518649	+	318	WP_167782832.1	YebG family protein	-
HC341_RS11790	2518696..2519181	-	486	WP_167782833.1	RES family NAD+ phosphorylase	Toxin
HC341_RS11795	2519178..2519624	-	447	WP_167782834.1	DUF2384 domain-containing protein	Antitoxin
HC341_RS11800	2519785..2520183	+	399	WP_167782835.1	phasin family protein	-
HC341_RS11805	2520310..2522580	-	2271	WP_167782836.1	hypothetical protein	-
HC341_RS11810	2522810..2523076	-	267	WP_167782241.1	transposase	-
HC341_RS11815	2523124..2524566	-	1443	WP_167784183.1	IS66 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (7-152)

Antitoxin

• Antitoxin Xre (18-147)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17527.99 Da
• Isoelectric Point: 7.3573

>T153126 WP_167782833.1 NZ_CP050695:c2519181-2518696 [Aquisalimonas sp. 2447]
MTDLVPAYRLVKARHADAAFDGEGARRFGGRWNSKGRPCVYVASSESLATLEVLVHLGQRQPLRGYALFHVRIPAASILY
LDEAALPANWRDPLPPAETAEIGDAWLTGAQSLALAVPSVVVPREVNYMLNPGHPEFAKVVTGAERGPFAFDERLQGQAP
R

Nucleotide

• Length: 486 bp

>T153126 NZ_CP066759:c2429679-2429401 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16431.51 Da
• Isoelectric Point: 6.8837

>AT153126 WP_167782834.1 NZ_CP050695:c2519624-2519178 [Aquisalimonas sp. 2447]
MEARNLYQPTSPGEGGFWARLGLPSRGAELHEALHRGFPYQVFRRLAELSGLDRKELARVTVIAPATLQRRSKAGRFSPD
ESDRLYRFAQVFKAALDLFDGDEAAASHWLTQPVQGLGDRRPVDMLATSAETQDVTDLIGRLEHGIAT

Nucleotide

• Length: 447 bp

>AT153126 NZ_CP066759:c2429872-2429681 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA