Detailed information of TA system TA153122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 199123..199670
• Replicon: chromosome
• Accession: NZ_CP050695
• Organism: Aquisalimonas sp. 2447

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HC341_RS00860
• Protein ID: WP_167780847.1
• Coordinates: 199368..199670 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HC341_RS00855
• Protein ID: WP_167780846.1
• Coordinates: 199123..199380 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC341_RS00835	194418..195515	+	1098	WP_167780844.1	Fic family protein	-
HC341_RS00840	195528..197008	+	1481	Protein_167	SAM-dependent DNA methyltransferase	-
HC341_RS00845	197241..198089	-	849	WP_167780845.1	hypothetical protein	-
HC341_RS00850	198298..198735	+	438	WP_174813702.1	hypothetical protein	-
HC341_RS00855	199123..199380	+	258	WP_167780846.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HC341_RS00860	199368..199670	+	303	WP_167780847.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HC341_RS00865	199770..200000	-	231	WP_167784066.1	glycoside hydrolase family 9 protein	-
HC341_RS00870	200025..200795	-	771	WP_167780848.1	exodeoxyribonuclease III	-
HC341_RS00875	200796..201233	-	438	WP_167780849.1	HIT family protein	-
HC341_RS00880	201616..203658	-	2043	WP_167780850.1	oligopeptidase A	-
HC341_RS00885	203874..204167	-	294	WP_167780851.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HC341_RS00890	204164..204361	-	198	WP_167784067.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	178210..199670	21460

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11660.31 Da
• Isoelectric Point: 4.2999

>T153122 WP_167780847.1 NZ_CP050695:199368-199670 [Aquisalimonas sp. 2447]
MAEVIWTETALQELEAIAEYIALDNSAAASHLVQEVFDKTERLEDFPQSGRIPPELPDSVYREVVIPPCRIFYREDEKRV
LVLYVMREERQLRVYMLGSS

Nucleotide

• Length: 303 bp

>T153122 NZ_CP066759:695517-695831 [Escherichia coli O157:H7]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9813.31 Da
• Isoelectric Point: 9.0323

>AT153122 WP_167780846.1 NZ_CP050695:199123-199380 [Aquisalimonas sp. 2447]
MKVELVTNLKRRATKILADLHASKEPVLITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAALEGRTCSQSEAREKM
SKWLR

Nucleotide

• Length: 258 bp

>AT153122 NZ_CP066759:695828-696244 [Escherichia coli O157:H7]
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA