Detailed information of TA system TA153121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 5510366..5510891
• Replicon: chromosome
• Accession: NZ_CP050692
• Organism: Streptomyces antibioticus strain DSM 41481

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HCX60_RS25285
• Protein ID: WP_030783763.1
• Coordinates: 5510366..5510629 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HCX60_RS25290
• Protein ID: WP_078634701.1
• Coordinates: 5510622..5510891 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCX60_RS25265	5506022..5507050	+	1029	WP_078634699.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
HCX60_RS25270	5507080..5507826	+	747	WP_030783755.1	ROK family protein	-
HCX60_RS25275	5508314..5508724	-	411	WP_037874973.1	hypothetical protein	-
HCX60_RS25280	5509214..5510302	+	1089	WP_078634700.1	redox-regulated ATPase YchF	-
HCX60_RS25285	5510366..5510629	-	264	WP_030783763.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HCX60_RS25290	5510622..5510891	-	270	WP_078634701.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HCX60_RS25295	5510935..5512353	-	1419	WP_167797378.1	hypothetical protein	-
HCX60_RS25300	5512388..5512705	-	318	WP_143648432.1	hypothetical protein	-
HCX60_RS25305	5512836..5514254	+	1419	WP_078634704.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10000.36 Da
• Isoelectric Point: 8.5814

>T153121 WP_030783763.1 NZ_CP050692:c5510629-5510366 [Streptomyces antibioticus]
VSEYRTVFRPEAQAELRKVPRDTALRILAKLTELESDPLGFNTTALVSQPDRRRLRVGDHRVIYTIDNGELVVWVVHVGH
RSTVYDT

Nucleotide

• Length: 264 bp

>T153121 NZ_CP066759:c653031-652567 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10363.82 Da
• Isoelectric Point: 4.9473

>AT153121 WP_078634701.1 NZ_CP050692:c5510891-5510622 [Streptomyces antibioticus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMANPARSIPIEDV
MRETLARSE

Nucleotide

• Length: 270 bp

>AT153121 NZ_CP066759:c653366-653031 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA