Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1407515..1407992 Replicon chromosome
Accession NZ_CP050691
Organism Staphylococcus aureus strain PMB196-1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HCU71_RS06755 Protein ID WP_000052076.1
Coordinates 1407515..1407703 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HCU71_RS06760 Protein ID WP_001059690.1
Coordinates 1407732..1407992 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU71_RS06725 1403509..1404030 + 522 WP_000824482.1 hypothetical protein -
HCU71_RS06730 1404371..1405057 + 687 WP_000141557.1 thermonuclease family protein -
HCU71_RS06735 1405414..1405614 + 201 WP_001059082.1 cold-shock protein -
HCU71_RS06740 1406106..1406324 - 219 WP_000005886.1 hypothetical protein -
HCU71_RS06745 1406386..1406670 - 285 WP_001004399.1 hypothetical protein -
HCU71_RS06750 1406758..1407327 - 570 WP_001106654.1 hypothetical protein -
HCU71_RS06755 1407515..1407703 - 189 WP_000052076.1 hypothetical protein Toxin
HCU71_RS06760 1407732..1407992 - 261 WP_001059690.1 hypothetical protein Antitoxin
HCU71_RS06765 1408333..1408536 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HCU71_RS06770 1408533..1408769 - 237 WP_000349581.1 hypothetical protein -
HCU71_RS06775 1408994..1409575 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
HCU71_RS06780 1409648..1410265 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
HCU71_RS06785 1410420..1410914 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
HCU71_RS06790 1411313..1411735 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
HCU71_RS06795 1411883..1412599 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T153109 WP_000052076.1 NZ_CP050691:c1407703-1407515 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T153109 NZ_CP066756:c4956237-4956064 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT153109 WP_001059690.1 NZ_CP050691:c1407992-1407732 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT153109 NZ_CP066756:c4956561-4956265 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References