153102

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1832739..1833253 Replicon chromosome
Accession NZ_CP050690
Organism Staphylococcus aureus strain PMB179-1

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag HCU70_RS08955 Protein ID WP_000581792.1
Coordinates 1833044..1833253 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag HCU70_RS08950 Protein ID WP_000138932.1
Coordinates 1832739..1833032 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU70_RS08925 1828088..1828729 + 642 WP_000483153.1 thiamine phosphate synthase -
HCU70_RS08930 1828815..1829687 + 873 WP_000725802.1 membrane protein insertase YidC -
HCU70_RS08940 1830414..1831061 - 648 WP_001187634.1 HD domain-containing protein -
HCU70_RS08945 1831089..1832573 - 1485 WP_000571549.1 cardiolipin synthase -
HCU70_RS08950 1832739..1833032 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
HCU70_RS08955 1833044..1833253 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
HCU70_RS08960 1833381..1833518 + 138 WP_000828354.1 hypothetical protein -
HCU70_RS08965 1833782..1834984 - 1203 WP_001109939.1 rod shape-determining protein RodA -
HCU70_RS08970 1835302..1836372 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
HCU70_RS08975 1836387..1837745 + 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T153102 WP_000581792.1 NZ_CP050690:1833044-1833253 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T153102 NZ_CP066756:3663850-3664236 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT153102 WP_000138932.1 NZ_CP050690:1832739-1833032 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT153102 NZ_CP066756:3664226-3664555 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References