153093

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 377583..378060 Replicon chromosome
Accession NZ_CP050690
Organism Staphylococcus aureus strain PMB179-1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HCU70_RS01865 Protein ID WP_000052076.1
Coordinates 377872..378060 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HCU70_RS01860 Protein ID WP_001059690.1
Coordinates 377583..377843 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU70_RS01830 372742..373236 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
HCU70_RS01835 373576..375222 + 1647 WP_000277718.1 IS1182 family transposase -
HCU70_RS01840 375310..375927 + 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
HCU70_RS01845 376000..376581 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
HCU70_RS01850 376806..377042 + 237 WP_000368687.1 hypothetical protein -
HCU70_RS01855 377039..377242 - 204 WP_000145164.1 sterile alpha motif-like domain-containing protein -
HCU70_RS01860 377583..377843 + 261 WP_001059690.1 hypothetical protein Antitoxin
HCU70_RS01865 377872..378060 + 189 WP_000052076.1 hypothetical protein Toxin
HCU70_RS01870 378248..378817 + 570 WP_001106654.1 hypothetical protein -
HCU70_RS01875 378905..379189 + 285 WP_001004401.1 hypothetical protein -
HCU70_RS01880 379251..379469 + 219 WP_000005886.1 hypothetical protein -
HCU70_RS01885 379965..380165 - 201 WP_001059082.1 cold-shock protein -
HCU70_RS01890 380522..381208 - 687 WP_167774940.1 thermonuclease family protein -
HCU70_RS01895 381549..382019 - 471 WP_000824467.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 373576..375222 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T153093 WP_000052076.1 NZ_CP050690:377872-378060 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T153093 NZ_CP066756:889098-889505 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT153093 WP_001059690.1 NZ_CP050690:377583-377843 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT153093 NZ_CP066756:888851-889117 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References