Detailed information of TA system TA153074

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1397239..1397732
• Replicon: chromosome
• Accession: NZ_CP050650
• Organism: Enterococcus faecium strain BIOPOP-3 WT

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HC354_RS06750
• Protein ID: WP_002292138.1
• Coordinates: 1397466..1397732 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HC354_RS06745
• Protein ID: WP_002292139.1
• Coordinates: 1397239..1397469 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC354_RS06720	1393152..1393910	+	759	WP_167779246.1	restriction endonuclease	-
HC354_RS06725	1394142..1394567	-	426	WP_119364934.1	toxin	-
HC354_RS06730	1394585..1394842	-	258	WP_002313665.1	hypothetical protein	-
HC354_RS06735	1394986..1395945	+	960	WP_002301399.1	IS30 family transposase	-
HC354_RS13600	1396109..1396411	+	303	Protein_1290	hypothetical protein	-
HC354_RS13605	1396427..1396763	+	337	Protein_1291	hypothetical protein	-
HC354_RS06745	1397239..1397469	+	231	WP_002292139.1	hypothetical protein	Antitoxin
HC354_RS06750	1397466..1397732	+	267	WP_002292138.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HC354_RS06755	1397984..1398211	+	228	Protein_1294	hypothetical protein	-
HC354_RS06760	1398227..1399393	+	1167	WP_167779247.1	oxygen-independent coproporphyrinogen III oxidase	-
HC354_RS06765	1399627..1400670	+	1044	WP_167779248.1	heat-inducible transcriptional repressor HrcA	-
HC354_RS06770	1400764..1401327	+	564	WP_002292135.1	nucleotide exchange factor GrpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1394986..1395945	959

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10556.21 Da
• Isoelectric Point: 10.3338

>T153074 WP_002292138.1 NZ_CP050650:1397466-1397732 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQIVVIAIQV
GHRKNVYD

Nucleotide

• Length: 267 bp

>T153074 NZ_CP066753:4189742-4189960 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8883.02 Da
• Isoelectric Point: 4.1943

>AT153074 WP_002292139.1 NZ_CP050650:1397239-1397469 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILREFGGLE

Nucleotide

• Length: 231 bp

>AT153074 NZ_CP066753:4189342-4189716 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG