Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907(toxin) |
Location | 657693..658264 | Replicon | chromosome |
Accession | NZ_CP050650 | ||
Organism | Enterococcus faecium strain BIOPOP-3 WT |
Toxin (Protein)
Gene name | mazF | Uniprot ID | R2Q2D5 |
Locus tag | HC354_RS03135 | Protein ID | WP_002341043.1 |
Coordinates | 657923..658264 (+) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A2A4E1M8 |
Locus tag | HC354_RS03130 | Protein ID | WP_025477367.1 |
Coordinates | 657693..657923 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HC354_RS03110 | 653957..654550 | + | 594 | WP_002329652.1 | malonate decarboxylase holo-ACP synthase | - |
HC354_RS03115 | 654574..655659 | + | 1086 | WP_002329651.1 | acyltransferase | - |
HC354_RS03120 | 655681..656550 | + | 870 | WP_002329650.1 | triphosphoribosyl-dephospho-CoA synthase MdcB | - |
HC354_RS03125 | 656662..657426 | + | 765 | Protein_579 | TIM44-like domain-containing protein | - |
HC354_RS03130 | 657693..657923 | + | 231 | WP_025477367.1 | hypothetical protein | Antitoxin |
HC354_RS03135 | 657923..658264 | + | 342 | WP_002341043.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
HC354_RS03140 | 658980..661082 | + | 2103 | WP_167779057.1 | PTS sugar transporter subunit IIA | - |
HC354_RS03145 | 661118..661420 | + | 303 | Protein_583 | PTS sugar transporter subunit IIB | - |
HC354_RS03150 | 661446..662735 | + | 1290 | WP_167779058.1 | PTS sugar transporter subunit IIC | - |
HC354_RS03155 | 662754..663161 | + | 408 | Protein_585 | tetratricopeptide repeat protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13316.66 Da Isoelectric Point: 9.9258
>T153072 WP_002341043.1 NZ_CP050650:657923-658264 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVLISQ
LKSLDFKERRLKKIENLPLQDMAKIDQIIQYMF
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVLISQ
LKSLDFKERRLKKIENLPLQDMAKIDQIIQYMF
Download Length: 342 bp
>T153072 NZ_CP066753:3567339-3567626 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8566.42 Da Isoelectric Point: 4.0070
>AT153072 WP_025477367.1 NZ_CP050650:657693-657923 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGRERL
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGRERL
Download Length: 231 bp
>AT153072 NZ_CP066753:3567148-3567339 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829AD04 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2A4E1M8 |