Detailed information of TA system TA153071

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1513177..1513670
• Replicon: chromosome
• Accession: NZ_CP050648
• Organism: Enterococcus faecium strain BIOPOP-3 ALE

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HC353_RS07425
• Protein ID: WP_002292138.1
• Coordinates: 1513404..1513670 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HC353_RS07420
• Protein ID: WP_002292139.1
• Coordinates: 1513177..1513407 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC353_RS07395	1509090..1509848	+	759	WP_167779246.1	restriction endonuclease	-
HC353_RS07400	1510080..1510505	-	426	WP_119364934.1	toxin	-
HC353_RS07405	1510523..1510780	-	258	WP_002313665.1	hypothetical protein	-
HC353_RS07410	1510924..1511883	+	960	WP_002301399.1	IS30 family transposase	-
HC353_RS13600	1512047..1512349	+	303	Protein_1423	hypothetical protein	-
HC353_RS13605	1512365..1512701	+	337	Protein_1424	hypothetical protein	-
HC353_RS07420	1513177..1513407	+	231	WP_002292139.1	hypothetical protein	Antitoxin
HC353_RS07425	1513404..1513670	+	267	WP_002292138.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HC353_RS07430	1513922..1514149	+	228	Protein_1427	hypothetical protein	-
HC353_RS07435	1514165..1515331	+	1167	WP_167779247.1	oxygen-independent coproporphyrinogen III oxidase	-
HC353_RS07440	1515565..1516608	+	1044	WP_167779248.1	heat-inducible transcriptional repressor HrcA	-
HC353_RS07445	1516702..1517265	+	564	WP_002292135.1	nucleotide exchange factor GrpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1510924..1511883	959

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10556.21 Da
• Isoelectric Point: 10.3338

>T153071 WP_002292138.1 NZ_CP050648:1513404-1513670 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQIVVIAIQV
GHRKNVYD

Nucleotide

• Length: 267 bp

>T153071 NZ_CP066753:c3341778-3341404 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8883.02 Da
• Isoelectric Point: 4.1943

>AT153071 WP_002292139.1 NZ_CP050648:1513177-1513407 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILREFGGLE

Nucleotide

• Length: 231 bp

>AT153071 NZ_CP066753:c3342199-3341825 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA