153070

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/-
Location 1510080..1510780 Replicon chromosome
Accession NZ_CP050648
Organism Enterococcus faecium strain BIOPOP-3 ALE

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag HC353_RS07400 Protein ID WP_119364934.1
Coordinates 1510080..1510505 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag HC353_RS07405 Protein ID WP_002313665.1
Coordinates 1510523..1510780 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC353_RS07370 1505161..1505604 + 444 WP_002345979.1 hypothetical protein -
HC353_RS07375 1505813..1506403 - 591 WP_002308925.1 glutamine amidotransferase -
HC353_RS07380 1507128..1507796 + 669 WP_002342166.1 zeta toxin family protein -
HC353_RS07385 1507789..1507950 + 162 WP_002342167.1 hypothetical protein -
HC353_RS07390 1508160..1508591 + 432 WP_002342168.1 N-6 DNA methylase -
HC353_RS07395 1509090..1509848 + 759 WP_167779246.1 restriction endonuclease -
HC353_RS07400 1510080..1510505 - 426 WP_119364934.1 toxin Toxin
HC353_RS07405 1510523..1510780 - 258 WP_002313665.1 hypothetical protein Antitoxin
HC353_RS07410 1510924..1511883 + 960 WP_002301399.1 IS30 family transposase -
HC353_RS13600 1512047..1512349 + 303 Protein_1423 hypothetical protein -
HC353_RS13605 1512365..1512701 + 337 Protein_1424 hypothetical protein -
HC353_RS07420 1513177..1513407 + 231 WP_002292139.1 hypothetical protein -
HC353_RS07425 1513404..1513670 + 267 WP_002292138.1 type II toxin-antitoxin system RelE/ParE family toxin -
HC353_RS07430 1513922..1514149 + 228 Protein_1427 hypothetical protein -
HC353_RS07435 1514165..1515331 + 1167 WP_167779247.1 oxygen-independent coproporphyrinogen III oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1510924..1511883 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16705.81 Da        Isoelectric Point: 4.6731

>T153070 WP_119364934.1 NZ_CP050648:c1510505-1510080 [Enterococcus faecium]
MNVISEGLYFEAADLANELSEEVSYYCSKKMEHVKCYDIENYVNEVEDVEFIDYDFKDNLSKKMLGSITKVHGEIIITTN
QHLMLERKNFTKMHEIIHYYKDVPYLGESHAFSDMILEDTYLPEDYKKTSSKYRCQYPHGE

Download         Length: 426 bp

>T153070 NZ_CP066753:3084111-3084218 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9913.09 Da        Isoelectric Point: 4.2290

>AT153070 WP_002313665.1 NZ_CP050648:c1510780-1510523 [Enterococcus faecium]
MLSNYQLVTVIADFFNVSTDFLLNRTSDPTPPKRSEEDQLGDSILSHFRLNTADMEVEDIEELEEELNEYMDFLVQRAKA
KKNKK

Download         Length: 258 bp

>AT153070 NZ_CP066753:c3084058-3083997 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References