Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | itaRT/DUF1778(antitoxin) |
| Location | 1835753..1836590 | Replicon | chromosome |
| Accession | NZ_CP050646 | ||
| Organism | Escherichia coli strain PapM-36-2 | ||
Toxin (Protein)
| Gene name | itaT | Uniprot ID | Q3Z4X7 |
| Locus tag | G6008_RS08995 | Protein ID | WP_000227784.1 |
| Coordinates | 1836048..1836590 (+) | Length | 181 a.a. |
Antitoxin (Protein)
| Gene name | itaR | Uniprot ID | I2UQS9 |
| Locus tag | G6008_RS08990 | Protein ID | WP_001297137.1 |
| Coordinates | 1835753..1836064 (+) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6008_RS08965 | 1830773..1831720 | + | 948 | WP_001239441.1 | cytochrome o ubiquinol oxidase subunit II | - |
| G6008_RS08970 | 1831742..1833733 | + | 1992 | WP_000467180.1 | cytochrome o ubiquinol oxidase subunit I | - |
| G6008_RS08975 | 1833723..1834337 | + | 615 | WP_000179819.1 | cytochrome o ubiquinol oxidase subunit III | - |
| G6008_RS08980 | 1834337..1834666 | + | 330 | WP_000019869.1 | cytochrome o ubiquinol oxidase subunit IV | - |
| G6008_RS08985 | 1834678..1835568 | + | 891 | WP_000971336.1 | heme o synthase | - |
| G6008_RS08990 | 1835753..1836064 | + | 312 | WP_001297137.1 | DUF1778 domain-containing protein | Antitoxin |
| G6008_RS08995 | 1836048..1836590 | + | 543 | WP_000227784.1 | GNAT family N-acetyltransferase | Toxin |
| G6008_RS09000 | 1836646..1837581 | - | 936 | WP_001365761.1 | sel1 repeat family protein | - |
| G6008_RS09005 | 1837989..1839353 | + | 1365 | WP_001000974.1 | MFS transporter | - |
| G6008_RS09010 | 1839481..1839972 | - | 492 | WP_001138904.1 | nucleotide binding protein YajQ | - |
| G6008_RS09015 | 1840140..1841051 | + | 912 | WP_000705874.1 | 2-dehydropantoate 2-reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 181 a.a. Molecular weight: 19805.02 Da Isoelectric Point: 8.3395
>T153051 WP_000227784.1 NZ_CP050646:1836048-1836590 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
Download Length: 543 bp
>T153051 NZ_CP066749:c23693-23541 [Escherichia coli O157:H7]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 104 a.a. Molecular weight: 11358.04 Da Isoelectric Point: 10.4825
>AT153051 WP_001297137.1 NZ_CP050646:1835753-1836064 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA
Download Length: 312 bp
>AT153051 NZ_CP066749:23748-23805 [Escherichia coli O157:H7]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|