153015

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1015002..1015653 Replicon chromosome
Accession NZ_CP050523
Organism Acinetobacter baumannii strain VB7036

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag HBM81_RS04910 Protein ID WP_000838146.1
Coordinates 1015002..1015184 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A009ITU8
Locus tag HBM81_RS04915 Protein ID WP_005070359.1
Coordinates 1015249..1015653 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBM81_RS04860 1010259..1010924 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
HBM81_RS04865 1010929..1011318 + 390 WP_000008492.1 hypothetical protein -
HBM81_RS04870 1011275..1011688 + 414 WP_071708264.1 glutamate 5-kinase -
HBM81_RS04875 1011697..1012101 + 405 WP_046122502.1 hypothetical protein -
HBM81_RS04880 1012073..1012441 + 369 WP_046122503.1 hypothetical protein -
HBM81_RS04885 1012443..1012841 + 399 WP_046122504.1 hypothetical protein -
HBM81_RS04890 1012843..1013055 + 213 WP_000121166.1 hypothetical protein -
HBM81_RS04895 1013163..1014092 + 930 WP_046122505.1 hypothetical protein -
HBM81_RS04900 1014137..1014670 + 534 WP_001185623.1 hypothetical protein -
HBM81_RS19620 1014784..1014933 + 150 WP_171249566.1 hypothetical protein -
HBM81_RS04910 1015002..1015184 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
HBM81_RS04915 1015249..1015653 + 405 WP_005070359.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HBM81_RS04920 1015734..1016135 + 402 WP_046122506.1 hypothetical protein -
HBM81_RS04925 1016196..1020164 + 3969 WP_046122507.1 tape measure protein -
HBM81_RS04930 1020282..1020623 + 342 WP_046122508.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 974770..1039941 65171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T153015 WP_000838146.1 NZ_CP050523:1015002-1015184 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T153015 NZ_CP066721:c2747066-2746971 [Staphylococcus xylosus]
ATGCTTATGATCTTCGTTCACATCATTGCACCAGTCATTAGTGGCTGTGCAGTTGCGTACTTTACTTACTGGCTTAGTAG
TAAACGCAATAAATAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14735.72 Da        Isoelectric Point: 4.4367

>AT153015 WP_005070359.1 NZ_CP050523:1015249-1015653 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT153015 NZ_CP066721:2746905-2746942 [Staphylococcus xylosus]
TATGCACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A009ITU8

References