153012

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4545787..4546444 Replicon chromosome
Accession NZ_CP050520
Organism Enterobacter sp. DNB-S2

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag HB664_RS21855 Protein ID WP_021242050.1
Coordinates 4545787..4546197 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag HB664_RS21860 Protein ID WP_010435322.1
Coordinates 4546178..4546444 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB664_RS21835 (HB664_21855) 4541780..4543513 - 1734 WP_219940211.1 single-stranded-DNA-specific exonuclease RecJ -
HB664_RS21840 (HB664_21860) 4543519..4544232 - 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HB664_RS21845 (HB664_21865) 4544261..4545157 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
HB664_RS21850 (HB664_21870) 4545259..4545780 + 522 WP_023309099.1 flavodoxin FldB -
HB664_RS21855 (HB664_21875) 4545787..4546197 - 411 WP_021242050.1 protein YgfX Toxin
HB664_RS21860 (HB664_21880) 4546178..4546444 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
HB664_RS21865 (HB664_21885) 4546739..4547719 + 981 WP_033146590.1 tRNA-modifying protein YgfZ -
HB664_RS21870 (HB664_21890) 4547783..4548442 - 660 WP_033146591.1 hemolysin III family protein -
HB664_RS21875 (HB664_21895) 4548608..4548919 - 312 WP_033146592.1 N(4)-acetylcytidine aminohydrolase -
HB664_RS21880 (HB664_21900) 4548971..4549702 + 732 WP_219940858.1 MurR/RpiR family transcriptional regulator -
HB664_RS21885 (HB664_21905) 4549819..4551252 + 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T153012 WP_021242050.1 NZ_CP050520:c4546197-4545787 [Enterobacter sp. DNB-S2]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T153012 NZ_CP066721:1106282-1106455 [Staphylococcus xylosus]
ATGAATTCAAATAAACAACAAAATGAATCTTTAGAACCTGAGAATGAAATGGTTGACGATTTCGATGATGTTGTTGAATT
AGGCAAAGAGATGGAACAAATTTCAGAGGAAAATGATGAAGATAAATTAGATAAATCACATGATGCTGAAGTACGTTCTG
ACCTTAATGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT153012 WP_010435322.1 NZ_CP050520:c4546444-4546178 [Enterobacter sp. DNB-S2]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT153012 NZ_CP066721:1105650-1106249 [Staphylococcus xylosus]
ATGGCAATGAACTTTAAAGTTTTAGAAAACGAAAGAGTTGTAGCTGAATATGCTGCAGATATTTTAAGAAAACAATTTAA
CAATAATCCAACAACTATCGCAGGTGTACATCTTGCTAATGACAATGCTCCTGTATTGGATGAATTGAAGAAAAATGTAG
ATAAAAATGCAGTAGATTTTAGTCAAATTAATATACTTGATTATGATGATAAGAAATCTTATTTTGAAGCATTAGGCGTA
CCAGAAGGTCAAATTTATAATGTATCACTTAGTGAAGACACTGAATCGTTTATCAAAGATAAGATTAAAACTAAAGAAAA
TAAAGGCAAATTAGTTACACAAGTACTTTCTATTGATACAAAAGGTAATTTAGACGTAAGTATCAAGCAAGGCCTTTTCT
CAGCACGTGAAGTGGTTTTAATCATTACTGGTAGTGAGAAAAAAGAAGTTGTTCATAAACTTTATGAAGAAAATGGTAAA
ACAAGTTTTGAACCTTCAGATTTAAAAGCTCACCGCATGGTTAATGTAATATTAGATGAAGCGGCTGCAGAAGGTTTACC
TGAAGATGTAAGACATTATTTCACAGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References