Detailed information of TA system TA153010

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4301430..4302114
• Replicon: chromosome
• Accession: NZ_CP050520
• Organism: Enterobacter sp. DNB-S2

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HB664_RS20755
• Protein ID: WP_219940854.1
• Coordinates: 4301791..4302114 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HB664_RS20750
• Protein ID: WP_101862777.1
• Coordinates: 4301430..4301753 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB664_RS20715 (HB664_20735)	4296987..4297427	+	441	WP_063410040.1	hypothetical protein	-
HB664_RS20720 (HB664_20740)	4297463..4297825	+	363	WP_219940145.1	hypothetical protein	-
HB664_RS20725 (HB664_20745)	4298221..4298565	+	345	WP_219940146.1	hypothetical protein	-
HB664_RS20730 (HB664_20750)	4298562..4299623	+	1062	WP_219940147.1	hypothetical protein	-
HB664_RS20735 (HB664_20755)	4299854..4300672	+	819	WP_219940148.1	DUF932 domain-containing protein	-
HB664_RS20740 (HB664_20760)	4300705..4301178	+	474	WP_130942920.1	DNA repair protein RadC	-
HB664_RS20745 (HB664_20765)	4301187..4301408	+	222	WP_219940149.1	DUF987 family protein	-
HB664_RS20750 (HB664_20770)	4301430..4301753	+	324	WP_101862777.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HB664_RS20755 (HB664_20775)	4301791..4302114	+	324	WP_219940854.1	TA system toxin CbtA family protein	Toxin
HB664_RS20760 (HB664_20780)	4302726..4303082	+	357	WP_029740047.1	hypothetical protein	-
HB664_RS20765 (HB664_20785)	4303257..4303814	+	558	WP_033146331.1	YceI family protein	-
HB664_RS20770 (HB664_20790)	4303806..4304597	-	792	WP_219940150.1	hypothetical protein	-
HB664_RS20775 (HB664_20795)	4304594..4305124	-	531	WP_081318797.1	RNA polymerase sigma factor	-
HB664_RS20780 (HB664_20800)	4305132..4305659	-	528	WP_033146334.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (10-106)

Antitoxin

• Antitoxin CbeA (4-102)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12138.75 Da
• Isoelectric Point: 4.7869

>T153010 WP_219940854.1 NZ_CP050520:4301791-4302114 [Enterobacter sp. DNB-S2]
ISSVPATVPVSSRLSPVQVWQQLLTYLLEQHYGLTLNDTPFHDDTAIEEHIDAGITLADAVNFLVEKYELVRIDRKGFSW
QEQTPYISVVDILRARRSTGLLKTNVE

Nucleotide

• Length: 324 bp

>T153010 NZ_CP066721:956380-956580 [Staphylococcus xylosus]
GTGCAATCAAAAATAATTTACGTCTCAGGTATTAATTCAGAACGACAATATCAAATAAAACAACGATTAATGAATGTTAT
AGGTGTACACAATGTTGCTATAGATAGTGATAAAGGAGAAATACTTGTCGATTTTGAAACACCTGCGAGTTTAAATAATT
TAGAAAAAGAAATTTATGATCTTGGATATCAAATATTTTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11983.69 Da
• Isoelectric Point: 7.0268

>AT153010 WP_101862777.1 NZ_CP050520:4301430-4301753 [Enterobacter sp. DNB-S2]
MQNSWGLKRDISPCFGARLVQEGCRLHFLADRAGISGTFNKDETLRLDQAFPLVMKQLELMLTTGELNPRHQHCVTLHHN
GLTCEADTLGSHGYVYIVIYPQASATQ

Nucleotide

• Length: 324 bp

>AT153010 NZ_CP066721:956072-956365 [Staphylococcus xylosus]
GTGACAGAAATACAAAAAGCACATCATTCAGACCAAATAAAATCAAATTTGAAATCAAGACTAAATAGAATAGAAGGGCA
AGTGCGAGCAATAAACCGTATGGTAGATGAAGATGTTTATTGTGACGATGTACTTACTCAAATTAGAGCGACACGTTCTG
CACTAAATAGCGTAGCAACTAAATTGTTGGATCATCATATGAAAAGTTGCATCATGGATAAAGTGGAAAAAGGTCAACAA
GAAGAAGCAATGGAAGAGTTATTAGTAACTTTTCAAAAATTAATGAAGGATTAG