Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3601232..3601822 Replicon chromosome
Accession NZ_CP050520
Organism Enterobacter sp. DNB-S2

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag HB664_RS17300 Protein ID WP_032658722.1
Coordinates 3601232..3601564 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag HB664_RS17305 Protein ID WP_033145928.1
Coordinates 3601565..3601822 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB664_RS17285 (HB664_17290) 3597396..3598721 + 1326 WP_069303042.1 SidA/IucD/PvdA family monooxygenase -
HB664_RS17290 (HB664_17295) 3598748..3600937 + 2190 WP_045142987.1 TonB-dependent siderophore receptor -
HB664_RS17300 (HB664_17305) 3601232..3601564 - 333 WP_032658722.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HB664_RS17305 (HB664_17310) 3601565..3601822 - 258 WP_033145928.1 antitoxin Antitoxin
HB664_RS17310 (HB664_17315) 3602114..3602503 - 390 WP_219939883.1 RidA family protein -
HB664_RS17315 (HB664_17320) 3602645..3603565 + 921 WP_126327674.1 LysR family transcriptional regulator -
HB664_RS17320 (HB664_17325) 3603640..3603942 - 303 WP_029741460.1 XRE family transcriptional regulator -
HB664_RS17325 (HB664_17330) 3603947..3604300 - 354 WP_219939884.1 type II toxin-antitoxin system RelE/ParE family toxin -
HB664_RS17330 (HB664_17335) 3604478..3605371 - 894 WP_219939885.1 LysR substrate-binding domain-containing protein -
HB664_RS17335 (HB664_17340) 3605545..3606150 + 606 WP_258235895.1 glutathione S-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11814.63 Da        Isoelectric Point: 9.4051

>T153008 WP_032658722.1 NZ_CP050520:c3601564-3601232 [Enterobacter sp. DNB-S2]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTTTTGVIRCDQPRTI
DMSARNGMRLERIPDAVVNEVLARLDAILN

Download         Length: 333 bp

>T153008 NZ_CP066719:953283-953483 [Staphylococcus xylosus]
GTGCAATCAAAAGTAATTTACGTCTCAGATATTAATTCAGAACGACAATATCAAATAAAACAACGATTAATGAATGTTAT
AGGTGTACATAATGTTGCTATAGATATTGACAAAGGAGAAATACTTGTCGATTTTGAAACACCTGCGAGTTTAAATAATT
TGGAAAAAGAAATTTATGATCTTGGATATCAAATATTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9464.92 Da        Isoelectric Point: 4.4737

>AT153008 WP_033145928.1 NZ_CP050520:c3601822-3601565 [Enterobacter sp. DNB-S2]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEEREWIDAPAV
GREIL

Download         Length: 258 bp

>AT153008 NZ_CP066719:952975-953268 [Staphylococcus xylosus]
GTGACAGAAATACAAAAAGCGCATCATTCAGACCAAATAAAATCAAATTTGAAATCAAGACTAAATAGAATAGAAGGGCA
AGTGCGAGCAATAAACCGTATGGTAGATGAAGATGTTTATTGTGACGATGTACTTACTCAAATTAGAGCGACACGTTCTG
CACTAAATAGCGTAGCAACTAAATTGTTGGATCATCATATGAAAAGTTGCATCATGGATAAAGTGGAAAAAGGTCAACAA
GAAGAAGCAATGGAAGAATTATTAGTAACTTTTCAAAAATTAATGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References