Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1747927..1748547 Replicon chromosome
Accession NZ_CP050520
Organism Enterobacter sp. DNB-S2

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag HB664_RS08240 Protein ID WP_008499287.1
Coordinates 1747927..1748145 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag HB664_RS08245 Protein ID WP_008499288.1
Coordinates 1748173..1748547 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB664_RS08210 (HB664_08205) 1743941..1744201 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
HB664_RS08215 (HB664_08210) 1744204..1744344 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HB664_RS08220 (HB664_08215) 1744341..1745051 - 711 WP_048978929.1 GNAT family protein -
HB664_RS08225 (HB664_08220) 1745153..1746613 + 1461 WP_219940602.1 PLP-dependent aminotransferase family protein -
HB664_RS08230 (HB664_08225) 1746585..1747052 - 468 WP_219940603.1 YlaC family protein -
HB664_RS08235 (HB664_08230) 1747170..1747721 - 552 WP_219940605.1 maltose O-acetyltransferase -
HB664_RS08240 (HB664_08235) 1747927..1748145 - 219 WP_008499287.1 HHA domain-containing protein Toxin
HB664_RS08245 (HB664_08240) 1748173..1748547 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
HB664_RS08250 (HB664_08245) 1749059..1752205 - 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit AcrB -
HB664_RS08255 (HB664_08250) 1752228..1753421 - 1194 WP_219940606.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T152998 WP_008499287.1 NZ_CP050520:c1748145-1747927 [Enterobacter sp. DNB-S2]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T152998 NZ_CP066714:856834-857187 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATCCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT152998 WP_008499288.1 NZ_CP050520:c1748547-1748173 [Enterobacter sp. DNB-S2]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT152998 NZ_CP066714:856663-856833 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References