152993

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 5152298..5152937 Replicon chromosome
Accession NZ_CP050509
Organism Peribacillus butanolivorans strain KJ40

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag GM240_RS24680 Protein ID WP_034306610.1
Coordinates 5152298..5152648 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag GM240_RS24685 Protein ID WP_034306380.1
Coordinates 5152656..5152937 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM240_RS24645 5147575..5148360 - 786 WP_056526373.1 RNA polymerase sigma factor SigB -
GM240_RS24650 5148338..5148811 - 474 WP_053348277.1 anti-sigma B factor RsbW -
GM240_RS24655 5148808..5149140 - 333 WP_056526370.1 anti-sigma factor antagonist -
GM240_RS24660 5149198..5150208 - 1011 WP_098176642.1 PP2C family protein-serine/threonine phosphatase -
GM240_RS24665 5150217..5150618 - 402 WP_053348280.1 anti-sigma regulatory factor -
GM240_RS24670 5150622..5150978 - 357 WP_034306376.1 STAS domain-containing protein -
GM240_RS24675 5150981..5151808 - 828 WP_053348281.1 STAS domain-containing protein -
GM240_RS24680 5152298..5152648 - 351 WP_034306610.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GM240_RS24685 5152656..5152937 - 282 WP_034306380.1 antitoxin EndoAI Antitoxin
GM240_RS24690 5153098..5154330 - 1233 WP_190271758.1 alanine racemase -
GM240_RS24695 5154506..5155510 - 1005 WP_190270463.1 outer membrane lipoprotein carrier protein LolA -
GM240_RS24700 5155745..5156101 - 357 WP_056526356.1 holo-ACP synthase -
GM240_RS24705 5156212..5156802 + 591 WP_098176645.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12955.06 Da        Isoelectric Point: 7.2029

>T152993 WP_034306610.1 NZ_CP050509:c5152648-5152298 [Peribacillus butanolivorans]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEPMMQKVNEALQISLGLIEF

Download         Length: 351 bp

>T152993 NZ_CP066713:179574-179840 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTTTTAATTAAGAATTCAGCCAAAAATGACTTAAAAAAAATTAAAAAGCCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTCAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTTCTGCTTGGTCACATTATGAGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.13 Da        Isoelectric Point: 5.9054

>AT152993 WP_034306380.1 NZ_CP050509:c5152937-5152656 [Peribacillus butanolivorans]
VSESSATREILIRLPQNFLTELDGYASEENVNRSEFIYRATKMYLRERKKKEFRESMKRGYIEMAAINLTIASEAFQAEF
EAGHCVERLVSGG

Download         Length: 282 bp

>AT152993 NZ_CP066713:179317-179574 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATAGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References