Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4361448..4362067 Replicon chromosome
Accession NZ_CP050508
Organism Raoultella terrigena strain JH01

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4Z516
Locus tag HCK03_RS20455 Protein ID WP_041144355.1
Coordinates 4361849..4362067 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8B4Z4D4
Locus tag HCK03_RS20450 Protein ID WP_041144356.1
Coordinates 4361448..4361822 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCK03_RS20440 4356610..4357791 + 1182 WP_041144358.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HCK03_RS20445 4357826..4360972 + 3147 WP_041144357.1 multidrug efflux RND transporter permease subunit -
HCK03_RS20450 4361448..4361822 + 375 WP_041144356.1 Hha toxicity modulator TomB Antitoxin
HCK03_RS20455 4361849..4362067 + 219 WP_041144355.1 hemolysin expression modulator Hha Toxin
HCK03_RS20460 4362217..4362783 + 567 WP_041144354.1 maltose O-acetyltransferase -
HCK03_RS20465 4362882..4363349 + 468 WP_041144353.1 YlaC family protein -
HCK03_RS20470 4363321..4364778 - 1458 WP_167692111.1 PLP-dependent aminotransferase family protein -
HCK03_RS20475 4364880..4365590 + 711 WP_167692112.1 GNAT family N-acetyltransferase -
HCK03_RS20480 4365587..4365727 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HCK03_RS20485 4365730..4365990 - 261 WP_041144350.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8580.94 Da        Isoelectric Point: 7.9907

>T152991 WP_041144355.1 NZ_CP050508:4361849-4362067 [Raoultella terrigena]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELPDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T152991 NZ_CP066712:803582-803935 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14397.16 Da        Isoelectric Point: 4.8886

>AT152991 WP_041144356.1 NZ_CP050508:4361448-4361822 [Raoultella terrigena]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIDHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINSVDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT152991 NZ_CP066712:803411-803581 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4Z516

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4Z4D4

References