Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2926508..2927409 Replicon chromosome
Accession NZ_CP050508
Organism Raoultella terrigena strain JH01

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HCK03_RS13795 Protein ID WP_115192781.1
Coordinates 2926948..2927409 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HCK03_RS13790 Protein ID WP_167691754.1
Coordinates 2926508..2926951 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCK03_RS13770 2922532..2923431 - 900 WP_167691751.1 LysR family transcriptional regulator -
HCK03_RS13775 2923699..2924910 + 1212 WP_167691752.1 SMP-30/gluconolactonase/LRE family protein -
HCK03_RS13780 2924988..2925617 - 630 WP_167691753.1 TetR/AcrR family transcriptional regulator -
HCK03_RS13785 2925655..2926368 + 714 WP_041145501.1 SDR family oxidoreductase -
HCK03_RS13790 2926508..2926951 + 444 WP_167691754.1 DUF2384 domain-containing protein Antitoxin
HCK03_RS13795 2926948..2927409 + 462 WP_115192781.1 RES family NAD+ phosphorylase Toxin
HCK03_RS13800 2927460..2927705 - 246 WP_041145498.1 YmjA family protein -
HCK03_RS13805 2927880..2928371 - 492 WP_045855351.1 GNAT family N-acetyltransferase -
HCK03_RS13810 2928467..2929144 - 678 WP_115192782.1 transporter substrate-binding domain-containing protein -
HCK03_RS13815 2929390..2929905 + 516 WP_167691755.1 hypothetical protein -
HCK03_RS13820 2929950..2931233 - 1284 WP_041145496.1 citrate synthase -
HCK03_RS13825 2931407..2932123 - 717 WP_041145495.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(32-89)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16811.16 Da        Isoelectric Point: 5.1554

>T152990 WP_115192781.1 NZ_CP050508:2926948-2927409 [Raoultella terrigena]
VILYRLTKSRFLTTAWSGFGAKEAGGRWNSVGTAMVYLSEAASLTMLETLVHINAPQLLDDFTLLSIDVPDDQVLTVDPA
SLPADWAREDAPARLARYGDEWAASAASAALRVPSALSPVEYNYLFNPQHPAVFDLLASVKRIPFRFDTRLKA

Download         Length: 462 bp

>T152990 NZ_CP066712:180687-180953 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTCTTAATTAAGAATTCAGCCAAAAATGACTTGAAAAAAATTAAAAAGTCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTCAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGCTTATATT
TTTTCTGCTTGGTCATATTATGAGTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16351.67 Da        Isoelectric Point: 7.3211

>AT152990 WP_167691754.1 NZ_CP050508:2926508-2926951 [Raoultella terrigena]
MKVYSPTENAEKKLSPWHAIGLDAEDGIALMGKISHGLEGSVARQISAWAEITPAELRKMSGIANTTFNRSIKSRFSADQ
SERLVRILRVIERAVELFEGDKEAAQKWMNEPNRALGWKTPAEVVSSETGALEVMRLITRVEHGVYS

Download         Length: 444 bp

>AT152990 NZ_CP066712:180430-180687 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TGTAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATAGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References