Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2839482..2840221 Replicon chromosome
Accession NZ_CP050508
Organism Raoultella terrigena strain JH01

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HCK03_RS13420 Protein ID WP_076947544.1
Coordinates 2839736..2840221 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HCK03_RS13415 Protein ID WP_115192720.1
Coordinates 2839482..2839748 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCK03_RS13395 2834665..2835765 - 1101 WP_141334603.1 amino acid ABC transporter permease -
HCK03_RS13400 2835781..2836959 - 1179 WP_115192718.1 amino acid ABC transporter permease -
HCK03_RS13405 2837025..2838050 - 1026 WP_041145578.1 amino acid ABC transporter substrate-binding protein -
HCK03_RS13410 2838741..2839343 + 603 WP_167691725.1 DJ-1/PfpI family protein -
HCK03_RS13415 2839482..2839748 + 267 WP_115192720.1 DUF1778 domain-containing protein Antitoxin
HCK03_RS13420 2839736..2840221 + 486 WP_076947544.1 GNAT family N-acetyltransferase Toxin
HCK03_RS13425 2840599..2841339 + 741 WP_123552335.1 amino acid ABC transporter ATP-binding protein -
HCK03_RS13430 2841350..2842048 + 699 WP_041145574.1 ABC transporter permease subunit -
HCK03_RS13435 2842058..2842813 + 756 WP_115192722.1 amino acid ABC transporter permease -
HCK03_RS13440 2842800..2843645 + 846 WP_123552337.1 transporter substrate-binding domain-containing protein -
HCK03_RS13445 2843668..2844189 + 522 WP_041145571.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
HCK03_RS13450 2844189..2844941 + 753 WP_167691726.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - mgtB 2839482..2869790 30308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17701.48 Da        Isoelectric Point: 9.8720

>T152989 WP_076947544.1 NZ_CP050508:2839736-2840221 [Raoultella terrigena]
VGHVTAPEPLSAFHQVAEFVSGETVLDDWLKHKGLKNQALGAARTFVVCKKDTKQIAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

>T152989 NZ_CP066711:824302-824655 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10134.55 Da        Isoelectric Point: 4.3837

>AT152989 WP_115192720.1 NZ_CP050508:2839482-2839748 [Raoultella terrigena]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPIIEKLL
ARKPQWDT

Download         Length: 267 bp

>AT152989 NZ_CP066711:824131-824301 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References