Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3462693..3463313 Replicon chromosome
Accession NZ_CP050506
Organism Enterobacter hormaechei strain CM18-242-2

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HCU35_RS16235 Protein ID WP_015571250.1
Coordinates 3463095..3463313 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HCU35_RS16230 Protein ID WP_006809850.1
Coordinates 3462693..3463067 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU35_RS16220 3457820..3459013 + 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HCU35_RS16225 3459036..3462182 + 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
HCU35_RS16230 3462693..3463067 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HCU35_RS16235 3463095..3463313 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HCU35_RS16240 3463522..3464073 + 552 WP_017383210.1 maltose O-acetyltransferase -
HCU35_RS16245 3464190..3464657 + 468 WP_017383209.1 membrane protein -
HCU35_RS16250 3464629..3466089 - 1461 WP_017383208.1 PLP-dependent aminotransferase family protein -
HCU35_RS16255 3466191..3466901 + 711 WP_017383207.1 GNAT family N-acetyltransferase -
HCU35_RS16260 3466898..3467038 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HCU35_RS16265 3467041..3467301 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T152972 WP_015571250.1 NZ_CP050506:3463095-3463313 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T152972 NZ_CP066699:4673656-4674060 [Rhodopseudomonas palustris]
GTGATCGTCATCGACACGTCGGCGATCATTGCGATCTTTCGCGAGGAACCAGAGGCAGCCCAGTTTGCGCGGCTGATCGC
CTCCGACGACCAACCGGTTCTATCCTCGGGCAATTTGCTGGAGACCGCGATCGTTCTTCGTGGACTAAAGGACATTCAGC
CAGCCAAAGCGGAACGATGGCTTGATGACTTTATCGCGGAGGCCGGCATCCGGATCGAGCCCGTGACCACCGAGCAGGCC
GGATATGCGCGTTCGGCGCATTTGCGGTTCGGGAAAGGGACCGGCCACAAAGCAGCTCTCAACTACGGAGATTGCTTCGC
CTATGCGCTGGCCAAAGCTTTGAATGCCCCCTTGCTGTGCAAGGGCAACGACTTTCCGCTGACCGATATTCCGCTTGTCG
CATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT152972 WP_006809850.1 NZ_CP050506:3462693-3463067 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT152972 NZ_CP066699:4673408-4673659 [Rhodopseudomonas palustris]
ATGCATCTCAACATCAAGAACGACGAAGCTCATCAGTTAGCGACAGAGCTGGCCCGCATGACCGGGGAAAGCCTCACTGC
GGCGGTGACCAATGCGCTGCGCGAACAGCTCGCACGCGAGCATCGTCGCCGCCAAACCGACCAGATCGCGCAACGACTGC
TGAAAATCGGAGGCCGGTACGCCGCATTACCTGACACCGGGAGAACTCCAGACGAGATTCTCGGTTACGATGAGAACGGA
TTGCCCACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References