Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2315838..2316577 Replicon chromosome
Accession NZ_CP050506
Organism Enterobacter hormaechei strain CM18-242-2

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag HCU35_RS10830 Protein ID WP_003857133.1
Coordinates 2316092..2316577 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag HCU35_RS10825 Protein ID WP_003857131.1
Coordinates 2315838..2316104 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU35_RS10805 2311313..2312299 + 987 WP_017382341.1 DUF979 domain-containing protein -
HCU35_RS10810 2312309..2313304 + 996 WP_017382342.1 DUF2891 domain-containing protein -
HCU35_RS10815 2313327..2314715 - 1389 WP_017382343.1 MFS transporter -
HCU35_RS10820 2314845..2315774 + 930 WP_026080525.1 LysR family transcriptional regulator -
HCU35_RS10825 2315838..2316104 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
HCU35_RS10830 2316092..2316577 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
HCU35_RS10835 2316628..2317197 - 570 WP_017382346.1 hypothetical protein -
HCU35_RS10840 2317213..2318178 - 966 WP_045338503.1 hypothetical protein -
HCU35_RS10845 2318433..2318761 + 329 Protein_2112 helix-turn-helix domain-containing protein -
HCU35_RS10850 2319190..2319636 + 447 WP_014069654.1 DUF3290 domain-containing protein -
HCU35_RS10855 2319646..2320281 + 636 WP_015570517.1 DUF421 domain-containing protein -
HCU35_RS10860 2320465..2321079 - 615 WP_080337195.1 NUDIX hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T152971 WP_003857133.1 NZ_CP050506:2316092-2316577 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T152971 NZ_CP066699:c4036756-4036226 [Rhodopseudomonas palustris]
ATGGCGGACATAGACGACGCGCCAAACCAGCCACGTTCCCGTCTGTCGGCTCCCGTTCCCCTGACGATTGCACATGATCT
GTCGGCGTTCGATTGCGGCGAGCCGGTGTTGAACGACTGGCTGCGCCAACGGGCACTCAAGAACGAAAGCCGCTTCTCGC
GCACCTACGTGGTGTGCGAGGGCAACCAGGTCGTTGGCTATTTCTGCGTTTCAGCGGGCGCGGTCGAGCGCGCCGCAGCG
CCGGGCAAGGTCCGCCGCAACGCGCCCGACGCGATCCCGGTGTCGGTGATCGGGCGACTGGCCGTCAGCCGCTCCCATGC
CGGAATAGGTCTCGGCGCCGACCTGCTTTCGGACGCGCTACGCCGGATCGCGCTGGCGTCGCAGAGCATCGGCATCGGCG
CTGTTCAGGTCCACGCCAAGGACGATGCGGCCAAACGCTTTTATCTGCGCTGCGCCGAATTCATCGAATATCCCCAAGAC
AGCCGGACGCTGTTCCTGCCGATCGAAACGGTAGTCGCGGCCTTGAGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT152971 WP_003857131.1 NZ_CP050506:2315838-2316104 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT152971 NZ_CP066699:c4037082-4036744 [Rhodopseudomonas palustris]
ATGGCAAAGTCGCGTGGCGCACCTGCAAAATCCGCTCGTCGTTCCGCTGCGGCCGCAGCGCGCGGCGCGACGTCTGACGC
CAAGGGCAGCATCAATCTGCGGATCGAGACGGGCACTCGCCAGCTCATCGACGATGCGGCGGCGGTCCTTGGGAAGACGC
GCACGGAATTCATGGTGGAGAGCGCCCGGCGGCAGGCGGTCGATGTGCTGCTCGATCAGCGCTTATTCACGCTCGATCCC
GAACGCTATGACGCCTTCATGCAGGCGCTCGACAATCCGCCCGCGCCGGGGCCGAAACTCAAGGCGTTGCTGCGTCGGGT
CCCGGCATGGCGGACATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References