Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 946339..946994 Replicon chromosome
Accession NZ_CP050505
Organism Neisseria gonorrhoeae strain BJ16148

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag HCR02_RS04865 Protein ID WP_003691083.1
Coordinates 946339..946758 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag HCR02_RS04870 Protein ID WP_003688410.1
Coordinates 946758..946994 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCR02_RS04845 941573..943114 - 1542 WP_003701286.1 multidrug efflux MFS transporter -
HCR02_RS04850 943262..944041 + 780 WP_003688416.1 (Fe-S)-binding protein -
HCR02_RS04855 944038..944739 + 702 WP_003688414.1 lactate utilization protein C -
HCR02_RS04860 944736..946190 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
HCR02_RS04865 946339..946758 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
HCR02_RS04870 946758..946994 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
HCR02_RS04875 947200..947445 - 246 WP_003706295.1 IS3 family transposase -
HCR02_RS04880 947442..948020 - 579 WP_003688041.1 IS3 family transposase -
HCR02_RS04885 948025..948453 - 429 WP_010360042.1 helix-turn-helix domain-containing protein -
HCR02_RS04890 948665..949051 + 387 Protein_958 IS110 family transposase -
HCR02_RS04895 949434..950324 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
HCR02_RS04900 950335..951501 - 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
HCR02_RS04905 951573..951860 - 288 WP_025455945.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T152960 WP_003691083.1 NZ_CP050505:c946758-946339 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T152960 NZ_CP066661:15413-15763 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT152960 WP_003688410.1 NZ_CP050505:c946994-946758 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT152960 NZ_CP066661:15156-15419 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References