Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4343513..4344345 Replicon chromosome
Accession NZ_CP050498
Organism Escherichia coli strain RM13322

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag HCR07_RS22075 Protein ID WP_000854753.1
Coordinates 4343513..4343887 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9QGA8
Locus tag HCR07_RS22080 Protein ID WP_001280948.1
Coordinates 4343977..4344345 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCR07_RS22050 4338656..4339294 + 639 WP_001145628.1 DUF1076 domain-containing protein -
HCR07_RS22055 4339585..4340949 + 1365 WP_000953522.1 EspK/GogB family type III secretion system effector -
HCR07_RS22060 4342153..4342722 - 570 WP_001290252.1 DUF4942 domain-containing protein -
HCR07_RS22065 4342819..4343016 - 198 WP_000839281.1 DUF957 domain-containing protein -
HCR07_RS22070 4343028..4343516 - 489 WP_000777552.1 hypothetical protein -
HCR07_RS22075 4343513..4343887 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
HCR07_RS22080 4343977..4344345 - 369 WP_001280948.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HCR07_RS22085 4344508..4344729 - 222 WP_000692311.1 DUF987 domain-containing protein -
HCR07_RS22090 4344792..4345268 - 477 WP_001186726.1 RadC family protein -
HCR07_RS22095 4345284..4345769 - 486 WP_000849571.1 antirestriction protein -
HCR07_RS22100 4345824..4346642 - 819 WP_001234620.1 DUF945 domain-containing protein -
HCR07_RS22105 4346742..4346975 - 234 WP_001119729.1 DUF905 family protein -
HCR07_RS22110 4347054..4347425 - 372 WP_064758448.1 hypothetical protein -
HCR07_RS22115 4347463..4348676 + 1214 WP_162860179.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T152952 WP_000854753.1 NZ_CP050498:c4343887-4343513 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T152952 NZ_CP066647:17357-17479 [Enterococcus faecium]
ATGAAAGGAGTAAGCCTTTTGTCCGCATATGAGACAATTCAAACCATTCTTGGTTTTGGTATGTTTACCATTGCTTTGAT
TAGTTTGATTGTAAATATGCTTAAAAATGACAAAAAGAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13609.50 Da        Isoelectric Point: 7.3991

>AT152952 WP_001280948.1 NZ_CP050498:c4344345-4343977 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT152952 NZ_CP066647:c17562-17461 [Enterococcus faecium]
CCCTCATTAACAGCACCGTTTAAAGAACGGCGGCTCAGATTAATTATTTATTGAGAAATAACCGATCCTCGCTAAAGTGA
CGGTTATTTCTTTTTGTCATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QGA8

References